Induction of indoleamine dioxygenase by interferon in mice: a study with different recombinant interferons and various cytokines
- PMID: 3128977
- DOI: 10.1016/s0006-291x(88)80705-8
Induction of indoleamine dioxygenase by interferon in mice: a study with different recombinant interferons and various cytokines
Abstract
Since it is important the availability of a specific marker for interferon induction in vivo, we investigated the effect of different recombinant interferons and various cytokines on indoleamine 2,3-dioxygenase activity. Although with different magnitude, recombinant interferon-alpha A/D (Bgl II) hybrid, interferon-gamma and tumor necrosis factor, all increase the activity of this enzyme, whereas interleukin-1, recombinant interferon-alpha A and interferon-alpha D do not induce this activity in mice lung tissue. Dexamethasone is able to inhibit indoleamine 2,3-dioxygenase induction by lipopolysaccharide or by interferon-alpha A/D but it fails to prevent the induction by interferon-gamma.
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