Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jul;30(7):624-629.
doi: 10.5152/tjg.2019.18665.

The relationship between fibrosis and nodule structure and esophageal varices

Arif Mansur Coşar  1 , Tolga Yakar  2 , Ender Serin  2 , Birol Özer  2 , Fazilet Kayaselçuk  3
Affiliations

The relationship between fibrosis and nodule structure and esophageal varices

Arif Mansur Coşar et al. Turk J Gastroenterol. 2019 Jul.

Abstract

Background/aims: The aim of the present study was to evaluate the histopathological findings of cirrhosis together with clinical and laboratory parameters, and to investigate their relationship with esophageal varices that are portal hypertension findings.

Materials and methods: A total of 67 (42 male and 25 female) patients who were diagnosed with cirrhosis were included in the study. The mean age of the patients was 51.6±19.0 (1-81) years. The biopsy specimens of the patients were graded in terms of fibrosis, nodularity, loss of portal area, central venous loss, inflammation, and steatosis. The spleen sizes were graded ultrasonographically, and the esophageal varices were graded endoscopically.

Results: In the multivariate regression analysis, there was a correlation between the advanced disease stage (Child-Pugh score odds ratio (OR): 1.47, 95% confidence interval (CI): 1.018-2.121, p=0.040), presence of micronodularity (OR: 0.318, 95% CI: 0.120-0.842, p=0.021), grade of central venous loss (OR: 5.231, 95% CI: 1.132-24.176, p=0.034), and presence of esophageal varicose veins.

Conclusion: Although thrombocytopenia and splenomegaly may predict the presence of large esophageal varices, cirrhosis histopathology is the main factor in the presence of varices.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors have no conflict of interest to declare.

References

    1. Garcia-Tsao G, Groszmann RJ, Fisher RL, Conn HO, Atterbury CE, Glickman M. Portal pressure, presence of gastroesophageal varices and variceal bleeding. Hepatology. 1985;5:419–24. doi: 10.1002/hep.1840050313. - DOI - PubMed
    1. Morali GA, Sniderman KW, Deitel KM, et al. Is sinusoidal portal hypertension a necessary factor for the development of hepatic ascites? J Hepatol. 1992;16:249–50. doi: 10.1016/S0168-8278(05)80128-X. - DOI - PubMed
    1. Casado M, Bosch J, Garcia-Pagan JC, et al. Clinical events after transjugular intrahepatic portosystemic shunt: correlation with hemodynamic findings. Gastroenterology. 1998;114:1296–303. doi: 10.1016/S0016-5085(98)70436-6. - DOI - PubMed
    1. Batts KP, Ludwig J. Chronic hepatitis. an update on terminology and reporting. Am J Surg Pathol. 1995;19:1409–17. doi: 10.1097/00000478-199512000-00007. - DOI - PubMed
    1. Arguedas MR, Heudebert GR, Eloubeidi MA, Abrams GA, Fallon MB. Cost-effectiveness of screening, surveillance, and primary prophylaxis strategies for oesophageal varices. Am J Gastroenterol. 2002;97:2441–52. doi: 10.1111/j.1572-0241.2002.06000.x. - DOI - PubMed