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. 1988 Mar 8;443(1-2):325-8.
doi: 10.1016/0006-8993(88)91627-7.

Acute ethanol treatment lowers hypophyseal portal plasma luteinizing hormone-releasing hormone (LH-RH) and systemic plasma LH levels in orchidectomized rats

M Ching  1 , M Valenca, A Negro-Vilar
Affiliations

Acute ethanol treatment lowers hypophyseal portal plasma luteinizing hormone-releasing hormone (LH-RH) and systemic plasma LH levels in orchidectomized rats

M Ching et al. Brain Res. .

Abstract

Acute ethanol (EtOH) treatment resulted in a significant decline in hypophyseal portal plasma levels of luteinizing hormone-releasing hormone (LH-RH) in orchidectomized rats. This was accompanied by a similar decrement in circulating luteinizing hormone (LH) without, however, modifying plasma follicle-stimulating hormone (FSH) levels at time when peak blood alcohol concentrations occurred. Thus, acute alcohol intoxication lowers circulating LH levels primarily by impairing hypothalamic neuronal secretion of LH-RH into the portal blood.

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