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. 2019 Nov;23(10):1790-1800.
doi: 10.1002/ejp.1453. Epub 2019 Jul 29.

Perception of phasic pain is modulated by smell and taste

Marianna Riello  1 , Maria Paola Cecchini  1 , Alice Zanini  1 , Miguel Di Chiappari  1 , Michele Tinazzi  1 , Mirta Fiorio  1
Affiliations

Perception of phasic pain is modulated by smell and taste

Marianna Riello et al. Eur J Pain. 2019 Nov.

Abstract

Background: Pain perception is a multimodal experience composed of sensory, emotional and cognitive dimensions. Accumulating evidence suggests that the chemical senses can influence pain perception, but their relation with phasic pain is still unknown. The aim of this study was to investigate the influence of smell and taste having different valence on phasic pain.

Methods: Twenty-eight healthy volunteers received sweet, bitter and neutral odours or gustatory substances while receiving painful stimuli consisting of electrical shocks. Tactile threshold, pain threshold and pain tolerance were collected using the psychophysical method of limits at baseline and in association with smell and taste. Perception of pain intensity and unpleasantness was measured with a numerical rating scale.

Results: Sweet smell induced lower ratings of pain intensity than bitter smell when stimuli were delivered at pain threshold. Sweet smell also induced lower ratings of pain unpleasantness than neutral smell when stimuli were delivered at pain tolerance. Sweet taste induced lower ratings of pain unpleasantness than bitter taste when stimuli were delivered at pain threshold. Conversely, pain threshold and pain tolerance per se were not affected by smell and taste.

Conclusions: These findings highlight an effect of sweet substances in reducing the subjective perception of pain intensity and unpleasantness associated to phasic pain.

Significance: By demonstrating the link between smell, taste and phasic pain this study may have a translational impact in clinical conditions characterized by so-called shock-like pain, such as neuropathic pain.

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References

REFERENCES

    1. Bartolo, M., Serrao, M., Gamgebeli, Z., Alpaidze, M., Perrotta, A., Padua, L., … Sandrini, G. (2013). Modulation of the human nociceptive flexion reflex by pleasant and unpleasant odors. Pain, 154(10), 2054-2059. https://doi.org/10.1016/j.pain.2013.06.032
    1. Bastuji, H., Frot, M., Perchet, C., Hagiwara, K., & Garcia-Larrea, L. (2018). Convergence of sensory and limbic noxious input into the anterior insula and the emergence of pain from nociception. Scientific Reports, 8(1), 13360. https://doi.org/10.1038/s41598-018-31781-z
    1. Bushnell, M. C., Čeko, M., & Low, L. A. (2013). Cognitive and emotional control of pain and its disruption in chronic pain. Nature Reviews Neuroscience, 14, 502-511. https://doi.org/10.1038/nrn3516
    1. Cecchini, M. P., Knaapila, A., Hoffmann, E., Boschi, F., Hummel, T., & Iannilli, E. (2019). A cross-cultural survey of umami familiarity in European countries. Food Quality and Preference, 74, 172-178. https://doi.org/10.1016/j.foodqual.2019.01.017
    1. Chang, L. J., Yarkoni, T., Khaw, M. W., & Sanfey, A. G. (2013). Decoding the role of the insula in human cognition: Functional parcellation and large-scale reverse inference. Cerebral Cortex, 23(3), 739-749. https://doi.org/10.1093/cercor/bhs065