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Review
. 2019 Jul;45(5):433-448.
doi: 10.1055/s-0039-1692700. Epub 2019 Jul 10.

Preanalytical Variables in Coagulation Testing: Setting the Stage for Accurate Results

Robert C Gosselin  1 , Richard A Marlar  2
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Free article
Review

Preanalytical Variables in Coagulation Testing: Setting the Stage for Accurate Results

Robert C Gosselin et al. Semin Thromb Hemost. 2019 Jul.
Free article

Abstract

Many preanalytical variables may affect the results of routine coagulation assays. While advances in laboratory instrumentation have partially addressed the laboratory's ability to recognize some of these variables, there remains an increased reliance on laboratory personnel to recognize the three potential areas where coagulation testing preanalytical issues may arise: (1) specimen collection (including patient selection), (2) specimen transportation and stability, and (3) specimen processing and storage. The purpose of this article is to identify the preanalytical variables associated with coagulation-related testing and provide laboratory practice recommendations in an effort to improve the quality of coagulation testing and accuracy of result reporting.

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Conflict of interest statement

Mr. Gosselin reports personal fees from Siemens Healthcare Diagnostics, during the conduct of the study; personal fees from Grifols Diagnostic Solutions, Machaon Laboratory, Ferrer & Poiret, Garrett & Co., NovoNordisk, outside the submitted work; and Board member of International Council for Standardization in Haematology (ICSH), former board member (2018) of North American Specialized Coagulation Laboratory Association (NASCOLA), former board member (2018) of International Society for Laboratory Hematology (ISLH), former associate editor for J Laboratory Hematol (former as of February 28, 2018).

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