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Meta-Analysis
. 2019 Jul 10;19(1):140.
doi: 10.1186/s12903-019-0841-2.

In vivo effectiveness and safety of probiotics on prophylaxis and treatment of oral candidiasis: a systematic review and meta-analysis

Affiliations
Meta-Analysis

In vivo effectiveness and safety of probiotics on prophylaxis and treatment of oral candidiasis: a systematic review and meta-analysis

Lijun Hu et al. BMC Oral Health. .

Abstract

Background: To systematically review and assess the in vivo effectiveness and safety of probiotics for prophylaxis and treating oral candidiasis.

Methods: A literature search for studies published in English until August 1, 2018 was conducted in the following databases: PubMed, EMBASE, Cochrane Library, and Web of Science. Randomized controlled clinical trials and experimental mouse animal model studies comparing probiotics (at any dosage and in any form) with control groups (placebo, blank control or other agents) and reporting outcomes of the prophylactic and therapeutic effects were considered for inclusion. A descriptive study and, potentially, a meta-analysis were planned.

Results: Six randomized controlled clinical trials and 5 controlled experiments of mouse animal models were included in the systematic review. Four randomized controlled clinical trials comparing a probiotics group with a placebo/blank control group in 480 elderly and denture wearers were included in the meta-analysis. The overall combined odds ratio of the (random effects) meta-analysis was 0.24 (95% CI =0.09-0.63, P < 0.01). The overall combined odds ratio of the (fixed effects) sensitivity analysis was 0.39 (95% CI =0.25-0.60, P < 0.01) by excluding a study with the smallest sample size. These analyses showed that there was a statistically significant difference in the effect of probiotics compared with the control groups in elderly and denture wearers. The remaining 2 studies compared probiotics with other agents in a population aged 18-75 years and children aged 6-14 years respectively, and were analyzed descriptively. Meta-analysis and descriptive analyses indicated that probiotics were potentially effective in reducing morbidity, improving clinical symptoms and reducing oral Candida counts in oral candidiasis. The biases of the included studies were low or uncertain. The relatively common complaints reported were gastrointestinal discomfort and unpleasant taste, and no severe adverse events were reported.

Conclusions: Probiotics were superior to the placebo and blank control in preventing and treating oral candidiasis in the elderly and denture wearers. Although probiotics showed a favorable effect in treating oral candidiasis, more evidence is required to warrant their effectiveness when compared with conventional antifungal treatments. Moreover, data on the safety of probiotics are still insufficient, and further research is needed.

Keywords: Clinical trial; Effectiveness; Mouse animal model; Oral candidiasis; Probiotics; Safety.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Trial flow and study selection
Fig. 2
Fig. 2
Risk of bias graph: the overall risk of each bias is presented as a percentage representing the risk in all the included studies
Fig. 3
Fig. 3
Risk of bias summary: the risk of each bias in each of the included studies is shown separately. Note: +,?, − indicate high, uncertain, and low bias, respectively
Fig. 4
Fig. 4
Odds ratio and 95% confidence intervals from individual studies. Forest plots evaluating the effect of probiotics (random-effect model). Note: events indicate the subjects with oral candidiasis
Fig. 5
Fig. 5
Sensitivity test: forest plot of odds ratio and 95% confidence intervals in studies at low risk of bias (fixed-effect model). Note: events indicate the subjects with oral candidiasis

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