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. 1988 Jan;7(1):29-35.
doi: 10.1002/j.1460-2075.1988.tb02780.x.

A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells

P Chavrier  1 , M Zerial, P Lemaire, J Almendral, R Bravo, P Charnay
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A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells

P Chavrier et al. EMBO J. 1988 Jan.

Abstract

Zinc fingers are DNA-binding domains present in several eukaryotic regulatory proteins. We have identified a mouse gene, Krox-20, encoding a protein with three zinc fingers and whose expression is activated during G0/G1 transition in cultured cells. Serum stimulation of quiescent cells leads to rapid and transient accumulation of Krox-20 mRNA, with kinetics similar to those of the c-fos proto-oncogene. The induction does not require de-novo protein synthesis. In the mouse, Krox-20 is expressed at low levels in tissues which contain rapidly dividing cells. These properties suggest that Krox-20 encodes a transcription control factor, possibly involved in the modulation of cell proliferation.

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References

    1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed
    1. Genes Dev. 1987 Jun;1(4):347-57 - PubMed
    1. Annu Rev Biochem. 1978;47:715-50 - PubMed
    1. Biochemistry. 1979 Nov 27;18(24):5294-9 - PubMed
    1. Nature. 1980 Jan 31;283(5746):445-53 - PubMed

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