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Multicenter Study
. 2019 Sep;8(11):5000-5011.
doi: 10.1002/cam4.2370. Epub 2019 Jul 10.

Clinicopathological features and prognostic validity of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems in colonic neuroendocrine neoplasms

Yu Zhang  1 , Liang Shang  2 , Pan-Pan Zhang  3 , Luo-Hai Chen  1 , Wei Wang  4 , Cheng Fang  4 , Meng Qiu  5 , Xing-Yu Feng  6 , Lin Zhou  7 , Meng Zhang  7 , Huang-Ying Tan  8 , Xu-Dong Qiu  8 , Hao Wang  9 , Rong Lin  10 , Qin Zhang  11 , Yu-Jie Zeng  12 , Kai-Zhou Jin  13 , Xian-Jun Yu  13 , Lin Shen  3 , Min-Hu Chen  1 , Jie Li  3 , Le-Ping Li  2 , Jie Chen  1
Affiliations
Multicenter Study

Clinicopathological features and prognostic validity of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems in colonic neuroendocrine neoplasms

Yu Zhang et al. Cancer Med. 2019 Sep.

Abstract

Purpose: This study aimed to investigate the characteristics of colonic neuroendocrine neoplasms (NENs) and to validate the prognostic value of the European Neuroendocrine Tumor Society (ENETS) and American Joint Committee on Cancer (AJCC) 8th staging systems.

Methods: A total of 167 and 1248 patients with colonic NENs from 12 medical centers across China and from the Surveillance, Epidemiology, and End Results (SEER) cancer registry in the United States, respectively, were reviewed. Patients were staged according to the ENETS and AJCC 8th staging systems.

Results: Clinicopathological features of colonic NENs in the Chinese cohort and SEER cohort were significantly distinct. In both the Chinese cohort and the SEER cohort, colonic neuroendocrine carcinoma (NEC) and mixed adeno-neuroendocrine carcinoma (MANEC) were more frequent in the midgut than in the hindgut. Tumors originating from the midgut tended to be larger and at a more advanced stage than those from the hindgut. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC.

Conclusions: Our study revealed that tumors originating from the midgut and the hindgut shared different clinicopathological features. The AJCC 8th staging system and the ENETS system appeared to have similar prognostic ability for colonic NEC/MANEC.

Keywords: clinicopathological features; colon; neuroendocrine neoplasms; tumor stage.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Kaplan‐Meier analysis of Chinese patients with well/moderately differentiated colonic NET according to both the ENETS and AJCC 8th staging systems (A), and Kaplan‐Meier analysis of patients with well/moderately differentiated colonic NET from the SEER database according to both the ENETS and AJCC 8th staging systems (B). Discrepancy between the numbers of patients at risk and the total size of the analytic cohort for each staging system is accounted for by the number of patients who were lost to follow‐up within 30 days. AJCC, American Joint Committee on Cancer; ENETS, European Neuroendocrine Tumor Society; NET, neuroendocrine tumor; SEER, Surveillance, Epidemiology, and End Results
Figure 2
Figure 2
Kaplan‐Meier analysis of Chinese patients with colonic NEC/MANEC according to the ENETS staging system (A), AJCC 8th staging system (B), and Kaplan‐Meier analysis of patients with colonic NEC/MANEC from the SEER database according to the ENETS staging system (C), AJCC 8th staging system (D). Discrepancy between the numbers of patients at risk and the total size of the analytic cohort for each staging system is accounted for by the number of patients who were lost to follow‐up within 30 days. AJCC, American Joint Committee on Cancer; ENETS, European Neuroendocrine Tumor Society; MANEC, Mixed adeno‐neuroendocrine carcinoma; NEC, neuroendocrine carcinoma; NET, neuroendocrine tumor; SEER, Surveillance, Epidemiology, and End Results
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