Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jun 21:13:658.
doi: 10.3389/fnins.2019.00658. eCollection 2019.

Prodromal and Early bvFTD: Evaluating Clinical Features and Current Biomarkers

Kasper Katisko  1 , Antti Cajanus  1 , Titta Korhonen  1 , Anne M Remes  1   2   3   4 , Annakaisa Haapasalo  5 , Eino Solje  1   2
Affiliations
Review

Prodromal and Early bvFTD: Evaluating Clinical Features and Current Biomarkers

Kasper Katisko et al. Front Neurosci. .

Abstract

Despite the current diagnostic criteria, early diagnostics of behavioral variant of frontotemporal dementia (bvFTD) has remained challenging. Patients with bvFTD often present with misleading psychiatric phenotype, and, on the other hand, impairment in memory functions have increasingly been reported. However, impaired episodic memory is currently considered as an exclusion criterion for bvFTD. Single biofluid-based or imaging biomarkers do not currently provide sufficient sensitivity or specificity for early bvFTD diagnosis at single-subject level, although studies have suggested improved accuracy with different biomarker combinations. In this mini review, we evaluate the core clinical features of early bvFTD and summarize the most potential imaging and fluid biomarkers for bvFTD diagnostics.

Keywords: C9orf72; GRN; biomarker; diagnostics; differential diagnostics; frontotemporal dementia; frontotemporal lobar degeneration; neuroimaging.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Abu-Rumeileh S., Mometto N., Bartoletti-Stella A., Polischi B., Oppi F., Poda R., et al. (2018). Cerebrospinal fluid biomarkers in patients with frontotemporal dementia spectrum: a single-center study. J. Alzheimers Dis. 66 551–563. 10.3233/jad-180409 - DOI - PubMed
    1. Adenzato M., Cavallo M., Enrici I. (2010). Theory of mind ability in the behavioural variant of frontotemporal dementia: an analysis of the neural, cognitive, and social levels. Neuropsychologia 48 2–12. 10.1016/j.neuropsychologia.2009.08.001 - DOI - PubMed
    1. Al Shweiki M., Steinacker P., Oeckl P., Hengerer P., Danek A., Fassbender K., et al. (2019). Neurofilament light chain as a blood biomarker to differentiate psychiatric disorders from behavioural variant frontotemporal dementia. J. Psychiatr. Res. 113 137–140. 10.1016/j.jpsychires.2019.03.019 - DOI - PubMed
    1. Alcolea D., Carmona-Iragui M., Suárez-Calvet M., Sánchez-Saudinós M. B., Sala I., Antón-Aguirre S., et al. (2014). Relationship between β-secretase, inflammation and core cerebrospinal fluid biomarkers for alzheimer’s disease. J. Alzheimer’s Dis. 42 157–167. 10.3233/JAD-140240 - DOI - PubMed
    1. Alcolea D., Vilaplana E., Suárez-Calvet M., Illán-Gala I., Blesa R., Clarimón J., et al. (2017). CSF sAPPβ, YKL-40, and neurofilament light in frontotemporal lobar degeneration. Neurology 89 178–188. 10.1212/WNL.0000000000004088 - DOI - PubMed