Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Jun 14:17:e00577.
doi: 10.1016/j.idcr.2019.e00577. eCollection 2019.

Community-acquired liver abscess caused by capsular genotype K2-ST375 hypervirulent Klebsiella pneumoniae isolates

Kosuke Hoashi  1 , Sohei Harada  2 , Yoshikazu Ishii  3 , Kotaro Aoki  3 , Shin Ishikawa  4 , Yusuke Oshiro  5 , Takashi Shinzato  5
Affiliations
Case Reports

Community-acquired liver abscess caused by capsular genotype K2-ST375 hypervirulent Klebsiella pneumoniae isolates

Kosuke Hoashi et al. IDCases. .

Abstract

Hypervirulent Klebsiella pneumoniae has been associated with community-acquired liver abscesses in relatively healthy subjects since the 1990s, occasionally accompanied by disseminated disease. While isolates of capsular genotype K1 belonging to sequence type (ST) 23 have been the most prominent causative pathogen of this syndrome, other virulent clones have been implicated sporadically in recent years. A 68-year-old woman with diabetes in Okinawa, Japan suffered from a K. pneumoniae liver abscess, which recurred after a prolonged antibacterial treatment. The clinical course was further complicated with multiple sites of dissemination. Another 45-year-old woman living in Okinawa without underlying conditions was also diagnosed with a community-acquired K. pneumoniae liver abscess, which was cured with antibacterial treatment alone. Both of the causative isolates carried rmpA and aerobactin genes, and were confirmed as capsular genotype K2 and ST375. K. pneumoniae K2-ST375 is a hypervirulent clone of epidemiological significance causing severe community-acquired infections in relatively healthy subjects. More information about clinical characteristics and molecular epidemiology of hypervirulent K. pneumoniae clones other than K1-ST23 should be accumulated.

Keywords: Capsular genotype K2; Community-acquired liver abscess; Hypervirulent Klebsiella pneumoniae; ST375.

PubMed Disclaimer

References

    1. Podschun R., Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev. 1998;11:589–603. - PMC - PubMed
    1. Wang J.H., Liu Y.C., Lee S.S., Yen M.Y., Chen Y.S., Wang J.H. Primary liver abscess due to Klebsiella pneumoniae in Taiwan. Clin Infect Dis. 1998;26:1434–1438. - PubMed
    1. Cheng N.C., Yu Y.C., Tai H.C., Hsueh P.R., Chang S.C., Lai S.Y. Recent trend of necrotizing fasciitis in Taiwan: focus on monomicrobial Klebsiella pneumoniae necrotizing fasciitis. Clin Infect Dis. 2012;55:930–939. - PubMed
    1. Prokesch B.C., TeKippe M., Kim J., Raj P., TeKippe E.M., Greenberg D.E. Primary osteomyelitis caused by hypervirulent Klebsiella pneumoniae. Lancet Infect Dis. 2016;16:e190–e195. - PubMed
    1. Chuang Y.P., Fang C.T., Lai S.Y., Chang S.C., Wang J.T. Genetic determinants of capsular serotype K1 of Klebsiella pneumoniae causing primary pyogenic liver abscess. J Infect Dis. 2006;193:645–654. - PubMed

Publication types

LinkOut - more resources