doi: 10.1007/BF01922916.
Possible regulation of membrane-associated cyclic AMP phosphodiesterase in rat cerebral cortex by lipids
- PMID: 31295
- DOI: 10.1007/BF01922916
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Possible regulation of membrane-associated cyclic AMP phosphodiesterase in rat cerebral cortex by lipids
Experientia.
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Abstract
Cyclic AMP phosphodiesterase (PDE) in membrane fraction from rat cerebral cortex was activated by Triton X-100, and treatment at alkaline pH and with phospholipase C. These results suggest that membrane PDE exists in a latent form and is influenced by microenvironmental changes within the membrane. Furthermore, the PDE, unlike soluble enzyme, is not influenced by a protein activator and Ca++.
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