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. 1978 Sep 15;34(9):1139-40.
doi: 10.1007/BF01922916.

Possible regulation of membrane-associated cyclic AMP phosphodiesterase in rat cerebral cortex by lipids

A Baba, T Tsukamoto, T Matsuda, H Iwata

Possible regulation of membrane-associated cyclic AMP phosphodiesterase in rat cerebral cortex by lipids

A Baba et al. Experientia. .

Abstract

Cyclic AMP phosphodiesterase (PDE) in membrane fraction from rat cerebral cortex was activated by Triton X-100, and treatment at alkaline pH and with phospholipase C. These results suggest that membrane PDE exists in a latent form and is influenced by microenvironmental changes within the membrane. Furthermore, the PDE, unlike soluble enzyme, is not influenced by a protein activator and Ca++.

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