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. 2019 Jun 26:10:1425.
doi: 10.3389/fmicb.2019.01425. eCollection 2019.

Hepatitis E Infection in HIV-Infected Patients

Antonio Rivero-Juarez  1 , Pedro Lopez-Lopez  1 , Mario Frias  1 , Antonio Rivero  1
Affiliations

Hepatitis E Infection in HIV-Infected Patients

Antonio Rivero-Juarez et al. Front Microbiol. .

Abstract

Background: The hepatitis E virus (HEV) represents a major cause of acute hepatitis worldwide. The majority of HEV cases occur in low-income countries, mainly Asia and Africa, where HEV causes large outbreaks associated with the consumption of contaminated water and high mortality in specific populations. In high-income countries, HEV infection is considered a zoonotic disease that is linked to the consumption of contaminated food. Although a high proportion of cases have self-limiting asymptomatic or subclinical infections, immunosuppression may modify the pathogenesis and clinical impact of this emerging disease.

Results and discussion: Here, we review the current knowledge about the epidemiology, diagnosis, clinical manifestations, management and prevention of HEV infection in HIV-infected subjects.

Conclusions: Despite the increasing knowledge about the pathogenesis, epidemiology and clinical impact of HEV infection, several major factors are faced by HIV-infected patients, including treatment recommendations, immunization and risk practices.

Keywords: HEV; HIV; diagnosis; epidemiology; prevention; treatment; zoonoses.

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Figures

FIGURE 1
FIGURE 1
Worldwide seroprevalence of anti-IgG hepatitis E virus in HIV-infected patients (A). Schematic representation of the distribution of hepatitis E IgG antibody seroprevalence. Worldwide seroprevalence of anti-IgG hepatitis E virus in HIV-infected patients using Wantai Diagnostics assay (B). Maps created based on the data obtained in Supplementary Table S1.
See this image and copyright information in PMC

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