Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jul;7(4):10.1128/microbiolspec.gpp3-0022-2018.
doi: 10.1128/microbiolspec.GPP3-0022-2018.

Immunology of Mycobacterium tuberculosis Infections

Jonathan Kevin Sia  1 , Jyothi Rengarajan  2
Affiliations
Review

Immunology of Mycobacterium tuberculosis Infections

Jonathan Kevin Sia et al. Microbiol Spectr. 2019 Jul.

Abstract

Tuberculosis (TB) is a serious global public health challenge that results in significant morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium tuberculosis (M. tuberculosis), which has evolved a wide variety of strategies in order to thrive within its host. Understanding the complex interactions between M. tuberculosis and host immunity can inform the rational design of better TB vaccines and therapeutics. This chapter covers innate and adaptive immunity against M. tuberculosis infection, including insights on bacterial immune evasion and subversion garnered from animal models of infection and human studies. In addition, this chapter discusses the immunology of the TB granuloma, TB diagnostics, and TB comorbidities. Finally, this chapter provides a broad overview of the current TB vaccine pipeline.

PubMed Disclaimer

References

    1. WHO. 2017. Global Tuberculosis Report. World Health Organization, Geneva, Switzerland. [PubMed]
    1. Abubakar I, Pimpin L, Ariti C, Beynon R, Mangtani P, Sterne JA, Fine PE, Smith PG, Lipman M, Elliman D, Watson JM, Drumright LN, Whiting PF, Vynnycky E, Rodrigues LC. 2013. Systematic review and meta-analysis of the current evidence on the duration of protection by bacillus Calmette-Guérin vaccination against tuberculosis. Health Technol Assess 17:1–372, v–vi 10.3310/hta17370. - DOI - PMC - PubMed
    1. Roy A, Eisenhut M, Harris RJ, Rodrigues LC, Sridhar S, Habermann S, Snell L, Mangtani P, Adetifa I, Lalvani A, Abubakar I. 2014. Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis. BMJ 349:g4643 10.1136/bmj.g4643. [PubMed] - DOI - PMC - PubMed
    1. Mangtani P, Abubakar I, Ariti C, Beynon R, Pimpin L, Fine PE, Rodrigues LC, Smith PG, Lipman M, Whiting PF, Sterne JA. 2014. Protection by BCG vaccine against tuberculosis: a systematic review of randomized controlled trials. Clin Infect Dis 58:470–480 10.1093/cid/cit790. [PubMed] - DOI - PubMed
    1. Turner RD, Chiu C, Churchyard GJ, Esmail H, Lewinsohn DM, Gandhi NR, Fennelly KP. 2017. Tuberculosis infectiousness and host susceptibility. J Infect Dis 216(Suppl 6):S636–S643 10.1093/infdis/jix361. [PubMed] - DOI - PMC - PubMed