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. 2019 Sep;16(9):e1900266.
doi: 10.1002/cbdv.201900266. Epub 2019 Aug 8.

Cytotoxic Spliceostatin Analogs from Pseudomonas sp

Hong Zhao  1 , Bei Zhang  1 , Lie-Feng Ma  2 , Lin-Mei Shi  3 , Zha-Jun Zhan  2
Affiliations

Cytotoxic Spliceostatin Analogs from Pseudomonas sp

Hong Zhao et al. Chem Biodivers. 2019 Sep.

Abstract

Two new spliceostatin analogs, designed as spliceostatins J and K (1 and 2), were isolated and identified from the culture of Pseudomonas sp., along with two known ones, FR901464 (3) and spliceostatin E (4). Their structures were elucidated by detailed interpretation of their spectroscopic data, especially 2D-NMR and HR-ESI-MS. Spliceostatin J (1) represented the first example of spliceostatins bearing an unusual hexahydrofuro[3,4-b]furan moiety. Biological assay showed all the isolated compounds except 1 displayed potent cytotoxic activities against two cancer cell lines (MDA-MB-231 and A-549). Structure-activity-relationship studies revealed that the tetrahydropyran ring in spliceostatin analogs was necessary for their bioactive retention.

Keywords: Pseudomonas; bacteria; biological activity; cytotoxicity; spliceostatin.

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References

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