doi: 10.1007/BF03189910.
Inducibility of rat brain drug-metabolizing enzymes
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- PMID: 3130250
- DOI: 10.1007/BF03189910
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Inducibility of rat brain drug-metabolizing enzymes
Eur J Drug Metab Pharmacokinet.
1987 Oct-Dec.
Abstract
Cytochrome P450 from rat brain mitochondrial and microsomal fractions was found to be inducible by 3-methylcholanthrene, both in quantity of enzyme and in activity towards 7-ethoxyresorufin, which is a model substrate for the cytochrome P450 isoform specifically induced by 3-methylcholanthrene. Conversely, a phenobarbital treatment resulted in an induction of the microsomal cytochrome P450 only. On the other hand, the microsomal 1-naphthol-UDP-glucuronosyl transferase and epoxide hydrolase seemed to be non-inducible by 3-methylcholanthrene or by phenobarbital. The toxicological implications of these data are discussed.
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