Statistics in pills: meta-analysis of rare events
- PMID: 31302610
- PMCID: PMC10270378
- DOI: 10.1136/ebmental-2019-300103
Statistics in pills: meta-analysis of rare events
Abstract
Meta-analysis of rare events requires special considerations regarding which statistical method to use. This is because standard meta-analytical models are not well suited for the task, especially when some of the identified studies have reported zero events in one or more treatment groups.
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Conflict of interest statement
Competing interests: None declared.
Similar articles
-
Practical guide to the meta-analysis of rare events.Evid Based Ment Health. 2018 May;21(2):72-76. doi: 10.1136/eb-2018-102911. Epub 2018 Apr 12. Evid Based Ment Health. 2018. PMID: 29650528 Free PMC article.
-
Zero-cell corrections in random-effects meta-analyses.Res Synth Methods. 2020 Nov;11(6):913-919. doi: 10.1002/jrsm.1460. Epub 2020 Oct 21. Res Synth Methods. 2020. PMID: 32991790
-
Statistical considerations in meta-analysis.Infect Dis Clin North Am. 2009 Jun;23(2):195-210, Table of Contents. doi: 10.1016/j.idc.2009.01.003. Infect Dis Clin North Am. 2009. PMID: 19393905 Review.
-
Random-effects meta-analysis of few studies involving rare events.Res Synth Methods. 2020 Jan;11(1):74-90. doi: 10.1002/jrsm.1370. Epub 2019 Aug 22. Res Synth Methods. 2020. PMID: 31348846
-
Approaches to heterogeneity in meta-analysis.Stat Med. 2001 Dec 15;20(23):3625-33. doi: 10.1002/sim.1091. Stat Med. 2001. PMID: 11746342 Review.
Cited by
-
Ketamine and other glutamate receptor modulators for depression in adults with unipolar major depressive disorder.Cochrane Database Syst Rev. 2021 Sep 12;9(9):CD011612. doi: 10.1002/14651858.CD011612.pub3. Cochrane Database Syst Rev. 2021. PMID: 34510411 Free PMC article.
-
Prevalence of endometriosis in Mayer-Rokitansky-Küster-Hauser syndrome variants: a systematic review and meta-analysis.Hum Reprod. 2025 Jun 1;40(6):1094-1109. doi: 10.1093/humrep/deaf057. Hum Reprod. 2025. PMID: 40246293 Free PMC article.
-
Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder.Cochrane Database Syst Rev. 2021 Oct 8;10(10):CD011611. doi: 10.1002/14651858.CD011611.pub3. Cochrane Database Syst Rev. 2021. PMID: 34623633 Free PMC article.