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. 2019 Jul 15;8(1):50.
doi: 10.1186/s40249-019-0557-1.

Elimination of onchocerciasis in Africa by 2025: the need for a broad perspective

Ed Cupp  1 , Mauricio Sauerbrey  2 , Vitaliano Cama  3 , Mark Eberhard  3 , Patrick J Lammie  4 , Thomas R Unnasch  5
Affiliations

Elimination of onchocerciasis in Africa by 2025: the need for a broad perspective

Ed Cupp et al. Infect Dis Poverty. .

Abstract

Background: In response to the recent publication "Is onchocerciasis elimination in Africa feasible by 2025: a perspective based on lessons learnt from the African control programmes" by Dadzie et al., it is important to clarify and highlight the positive and unequivocal research and operational contributions from the American experience towards the worldwide elimination of human onchocerciasis (river blindness).

Main text: The strategies of twice or more rounds of mass drug administration (MDA) of ivermectin per year, as well as the use of OV-16 serology have allowed four American countries to be verified by World Health Organization to have eliminated transmission of Onchocerca volvulus, the etiological agent. These advances were also implemented in Sudan and Uganda; currently, both are the only African countries where ivermectin MDA was safely stopped in several transmission zones.

Conclusions: Programmatic treatment and evaluation approaches, pioneered in the Americas, are the most efficient among the existing tools for elimination, and their broader use could catalyze the successful elimination of this disease in Africa.

Keywords: Elimination, African Programme for onchocerciasis control; Ivermectin; Onchocerciasis; Onchocerciasis control program of West Africa; Onchocerciasis in the Americas.

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Conflict of interest statement

The authors declare that they have no financial or non-financial competing interests.

Comment on

References

    1. Dadzie Y, Amazigo UV, Boatin BA, Seketeli A. Is onchocerciasis elimination in Africa feasible by 2025: a perspective based on lessons learnt from the African control programmes. Inf Dis Poverty. 2018;7(1):63. doi: 10.1186/s40249-018-0446-z. - DOI - PMC - PubMed
    1. Colebunders R, J YC, Olore PC, Puok K, Bhattacharyya S, Menon S, et al. High prevalence of onchocerciasis-associated epilepsy in villages in Maridi County, republic of South Sudan: a community-based survey. Seizure. 2018;63:93–101. doi: 10.1016/j.seizure.2018.11.004. - DOI - PMC - PubMed
    1. Robles R. Onchocercose hujaine au Guatémala produisant le cécité el “ l’érysipele du litoral” (Erisipela de la costa) Bull Soc Pathol Exot. 1919;7:442–463.
    1. Casis-Sacre G. El syndrome epiléptico y sus relaciones con la oncocercosis. Bol Salubre Hig (Mexico) 1938;1:11–31.
    1. Nicholls RS, Duque S, Olaya LA, Lopez MC, Sanchez SB, Morales AL, et al. Elimination of onchocerciasis from Colombia: first proof of concept of river blindness elimination in the world. Parasit Vectors. 2018;11(1):237. doi: 10.1186/s13071-018-2821-9. - DOI - PMC - PubMed

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