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. 1988 Feb;79(2):204-11.
doi: 10.1111/j.1349-7006.1988.tb01578.x.

Genotoxicity of a variety of hydrazine derivatives in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes

H Mori  1 , S Sugie, N Yoshimi, H Iwata, A Nishikawa, K Matsukubo, H Shimizu, I Hirono
Affiliations

Genotoxicity of a variety of hydrazine derivatives in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes

H Mori et al. Jpn J Cancer Res. 1988 Feb.

Abstract

The genotoxicity of a variety of hydrazine derivatives was examined in the DNA-repair test on rat or mouse hepatocytes. Out of 32 hydrazine derivatives, 6 chemicals, i.e., N'-acetyl-4-(hydroxymethyl)phenylhydrazine, 1,2-dimethylhydrazine.2HCl, 1-hydrazinophthalazine.HCl, methylhydrazine.sulfate, p,p'-oxybisbenzene disulfonylhydrazide and phenylhydrazine.HCl, elicited positive DNA repair responses in the test on rat hepatocytes. In the test on mouse hepatocytes, 4 more hydrazine derivatives, i.e., 1,1-dimethylhydrazine, hydrazine hydrate, hydrazine sulfate and 2-methyl-4-chlorophenoxyacetic acid hydrazide.HCl also generated positive responses, in addition to the 6 positive compounds in the rat assay. These results suggest that mouse hepatocytes are more susceptible to the genotoxicity of hydrazine derivatives, and that the species differences in genotoxicity appear to be in agreement with the in vivo carcinogenicity of these agents.

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References

    1. ) Toth , B.Synthetic and naturally occurring hydrazines as possible cancer causative agents . Cancer Res. , 35 , 3693 – 3697 ( 1975. ). - PubMed
    1. ) Toth , B.Synthetic and naturally occurring hydrazines and cancer . J. Environ. Sci. Health , C2 , 51 – 102 ( 1984. ).
    1. ) Juhäsz , J. , Balö , J. and Kendrey , G.Über die Geschwulsterzeugende Wirkung des Isonicotinsäurehydrazide (INH) . Z. Krebsforsch. , 62 , 188 – 196 ( 1957. ). - PubMed
    1. ) Mori , K. and Yasuda , A.Preliminary note on the induction of pulmonary tumors in mice by isonicotinic acid hydrazide feeding . Gann , 50 , 107 – 110 ( 1959. ). - PubMed
    1. ) Toth , B. , Nagel , D. , Patil , K. , Erickson , J. and Antoson , K.Tumor induction with the N'‐acetyl derivative of 4 ‐hydroxymethyl‐phenylhydrazine, a metabolite of agaritine of Agaricus bisporus . Cancer Res. , 38 , 177 – 180 ( 1978. ). - PubMed

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