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. 2019 Jul;26(5):1089-1092.
doi: 10.1016/j.sjbs.2018.05.007. Epub 2018 May 3.

Chemical composition and antimicrobial, antioxidant, and anti-inflammatory activities of Lepidium sativum seed oil

Fulwah Yahya Alqahtani  1 , Fadilah Sfouq Aleanizy  1 , Amany Z Mahmoud  1   2 , Nida Nayyar Farshori  3 , Rihaf Alfaraj  1 , Ebtesam Saad Al-Sheddi  3 , Ibrahim A Alsarra  4
Affiliations

Chemical composition and antimicrobial, antioxidant, and anti-inflammatory activities of Lepidium sativum seed oil

Fulwah Yahya Alqahtani et al. Saudi J Biol Sci. 2019 Jul.

Abstract

Lepidium sativum (garden cress) seed oil was examined for its antimicrobial, antioxidant, and anti-inflammatory activities. The oil was obtained by hydrodistillation, where gas chromatography coupled with mass spectrometry that utilized to study its chemical composition. Microdilution method was used to test the antimicrobial effect of oil against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica, Klebsiella pneumoniae, and Candida albicans. The antioxidant activity was assessed by radical scavenging activity assay using 2,2-diphenyl-1-picrylhydrazyl radical. The major constituents found in the oil were 7,10-hexadecadienoic acid, 11-octadecenoic acid, 7,10,13-hexadecatrienoic acid, and behenic acid. The minimum inhibitory concentration (MIC) against all pathogens was 47.5 mg/ml, except for Salmonella enterica, which showed MIC of 90 mg/ml. The oil demonstrated antioxidant activity in a dose dependent pattern, with a half maximal inhibitory concentration (IC50) value of 40 mg/ml, and exerted anti-inflammatory activity, wherein 21% protection was shown at a concentration of 300 μg/ml. Thus, L. sativum seed oil shows antimicrobial, antioxidant, and anti-inflammatory properties.

Keywords: Anti-inflammatory activity; Antimicrobial activity; Antioxidant activity; Chemical composition; Lepidium sativum oil.

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Figures

Fig. 1
Fig. 1
Anti-inflammatory activity of Lepidium sativum seed oil.
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