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Case Reports
. 2019 May 7:33:7.
doi: 10.11604/pamj.2019.33.7.18971. eCollection 2019.

Diabetic-ketoacidosis in a nine-year-old child with homozygous sickle cell anaemia: a rare case report

Affiliations
Case Reports

Diabetic-ketoacidosis in a nine-year-old child with homozygous sickle cell anaemia: a rare case report

Nuraddeen Ibrahim et al. Pan Afr Med J. .

Abstract

Sickle cell anaemia (SCA) and type 1 diabetes mellitus (type 1 DM) are chronic medical conditions whose co-existence is uncommon in childhood. Furthermore, complications of SCA such as mesenteric crisis typically present with abdominal pain, which is also common in children with diabetic ketoacidosis (DKA) and this may possess diagnostic challenge. Herewith in, we report a rare case of a nine-year-old child with homozygous sickle cell anaemia, who presented with features of mesenteric crisis and diabetic ketoacidosis. The DKA was diagnosed based on the presence of hyperglycaemia (32.2 mmol/L), ketonaemia (4.6 mmol/L) and acidosis (11.6 mmol/L). The fluids deficit was corrected over 24 hours, with improvement in the vaso-occlusive crises (VOC) without precipitating cerebral oedema.

Keywords: Type I diabetes mellitus; child; diabetic ketoacidosis; mesenteric crisis; sickle cell anaemia.

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Conflict of interest statement

The authors declare no competing interests.

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References

    1. Frederic B, Anand P, Simon I. Global epidemiology of sickle cell haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates. Lancet. 2013;381(9861):42–151. Epub 2012 Oct 25. - PMC - PubMed
    1. Nwogoh B, Adewoyin A, Iheanacho O, Bazuaye G. Prevalence of haemoglobin variants in Benin city, Nigeria. Ann Biomed Sci. 2012;11(2):60–64.
    1. Jiya NM, Umar A, Ibrahim KK, Mohammed K, Erhabor O. Sickle Cell Anaemia: a prevalence study among the children attending Usmanu Danfodiyo University Teaching Hospital, Sokoto, North-Western Nigeria. Asian J Med Heal. 2017;2(2):2–8.
    1. Smiley D, Dagogo-jack S, Umpierrez G. Therapy Insight: metabolic and endocrine disorders in sickle cell disease. Nat Clin Pract. 2008;4(2):102–109. - PubMed
    1. Cresio A, Zilda B. Endocrine disorders in sickle cell disease. Curr Pediatr Rev. 2011;7(1):68–72.

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