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. 2013 Dec 17;48(6):471-474.
doi: 10.1016/j.rboe.2013.12.002. eCollection 2013 Nov-Dec.

Is osteoarthritis a mechanical or inflammatory disease?

Márcia Uchôa de Rezende  1 , Gustavo Constantino de Campos  1
Affiliations

Is osteoarthritis a mechanical or inflammatory disease?

Márcia Uchôa de Rezende et al. Rev Bras Ortop. .

Abstract
in English, Portuguese

Traditionally considered "wear and tear" disease, the pathogenic mechanisms of osteoarthritis have not yet been elucidated. The increasing number of articles demonstrating the influence of inflammatory factors in the onset and progression of the disease currently raises great debate in the literature about the importance of each of the factors involved in the disease. Even the choice between the terms "Osteoarthritis" and "Osteoarthrosis" generates controversy, since the first term implies the presence of inflammation as the key generator of the disease, and the latter denotes a degenerative/mechanical causal factor. The aim of this revision article is to promote a debate on the influence of inflammatory factors and mechanical factors in the pathogenesis of OA.

Classicamente considerada uma doença de wear and tear (desgaste), a osteoartrite ainda não tem elucidados todos os seus mecanismos patogênicos. O crescente número de artigos que demonstram a influência dos fatores inflamatórios no surgimento e na evolução da doença suscita, atualmente, grande debate na literatura sobre a importância de cada um dos fatores envolvidos. Até mesmo a escolha dos termos osteoartrite e osteoartrose gera polêmica, uma vez que o primeiro implica a presença da inflamação como fator primordial gerador da doença e o último denota um fator causal degenerativo/mecânico. O objetivo deste artigo é promover um debate sobre a influência dos fatores inflamatórios e dos fatores mecânicos na patogênese da OA.

Keywords: Arthritis; Chronic disease; Inflammation; Mechanics; Osteoarthritis.

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