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. 2018 Mar 28:1:10.
doi: 10.1038/s41746-018-0018-4. eCollection 2018.

Digital biomarkers of cognitive function

Paul Dagum  1
Affiliations

Digital biomarkers of cognitive function

Paul Dagum. NPJ Digit Med. .

Abstract

To identify digital biomarkers associated with cognitive function, we analyzed human-computer interaction from 7 days of smartphone use in 27 subjects (ages 18-34) who received a gold standard neuropsychological assessment. For several neuropsychological constructs (working memory, memory, executive function, language, and intelligence), we found a family of digital biomarkers that predicted test scores with high correlations (p < 10-4). These preliminary results suggest that passive measures from smartphone use could be a continuous ecological surrogate for laboratory-based neuropsychological assessment.

Keywords: Diagnostic markers; Predictive markers.

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Conflict of interest statement

Competing InterestsThis paper describes results from the use of a proprietary product for which the author holds multiple US patents. The author is a significant share holder of Mindstrong Health that owns the intellectual property for commercial use.

Figures

Fig. 1
Fig. 1
A blue square represents a participant test Z-score normed to the 27 participant scores and a red circle represents the digital biomarker prediction Z-score normed to the 27 predictions. Test scores and predictions shown are a digits backward, b symbol digit modality, c animal fluency, d Wechsler memory Scale-3rd Edition (WMS-III) logical memory (delayed free recall), e brief visuospatial memory test (delayed free recall), and f Wechsler adult intelligence scale-4th Edition (WAIS-IV) block design
See this image and copyright information in PMC

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