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. 2019 Nov;19(11):3162-3175.
doi: 10.1111/ajt.15532. Epub 2019 Aug 21.

Blood CD9+ B cell, a biomarker of bronchiolitis obliterans syndrome after lung transplantation

Carole Brosseau  1   2   3   4 , Richard Danger  1   2 , Maxim Durand  1   2   5 , Eugénie Durand  1   2 , Aurore Foureau  3   4 , Philippe Lacoste  3   4 , Adrien Tissot  1   2   3   4   5 , Antoine Roux  6   7 , Martine Reynaud-Gaubert  8 , Romain Kessler  9 , Sacha Mussot  10 , Claire Dromer  11 , Olivier Brugière  12 , Jean François Mornex  13 , Romain Guillemain  14 , Johanna Claustre  15 , Antoine Magnan  3   4 , Sophie Brouard  1   2   16 ; COLT and SysCLAD Consortia
Collaborators, Affiliations
Free article

Blood CD9+ B cell, a biomarker of bronchiolitis obliterans syndrome after lung transplantation

Carole Brosseau et al. Am J Transplant. 2019 Nov.
Free article

Abstract

Bronchiolitis obliterans syndrome is the main limitation for long-term survival after lung transplantation. Some specific B cell populations are associated with long-term graft acceptance. We aimed to monitor the B cell profile during early development of bronchiolitis obliterans syndrome after lung transplantation. The B cell longitudinal profile was analyzed in peripheral blood mononuclear cells from patients with bronchiolitis obliterans syndrome and patients who remained stable over 3 years of follow-up. CD24hi CD38hi transitional B cells were increased in stable patients only, and reached a peak 24 months after transplantation, whereas they remained unchanged in patients who developed a bronchiolitis obliterans syndrome. These CD24hi CD38hi transitional B cells specifically secrete IL-10 and express CD9. Thus, patients with a total CD9+ B cell frequency below 6.6% displayed significantly higher incidence of bronchiolitis obliterans syndrome (AUC = 0.836, PPV = 0.75, NPV = 1). These data are the first to associate IL-10-secreting CD24hi CD38hi transitional B cells expressing CD9 with better allograft outcome in lung transplant recipients. CD9-expressing B cells appear as a contributor to a favorable environment essential for the maintenance of long-term stable graft function and as a new predictive biomarker of bronchiolitis obliterans syndrome-free survival.

Keywords: B cell biology; basic (laboratory) research/science; biomarker; bronchiolitis obliterans (BOS); lung transplantation/pulmonology; translational research/science.

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References

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