doi: 10.1073/pnas.76.5.2430.
Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines
- PMID: 313056
- PMCID: PMC383615
- DOI: 10.1073/pnas.76.5.2430
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Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines
Proc Natl Acad Sci U S A.
1979 May.
Abstract
Human malignant T cell lines have high levels of deoxyribonucleoside phosphorylating activity and low levels of deoxyribonucleotide dephosphorylating activity. When incubated with deoxyadenosine or thymidine, the malignant T cell lines rapidly accumulate toxic concentrations of dATP and dTTP, respectively. This unusual pattern of deoxyribonucleotide metabolism renders the malignant T cells especially vulnerable to the toxic effects of deoxyribonucleosides and related analogues.
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