Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 May;76(5):2430-3.
doi: 10.1073/pnas.76.5.2430.

Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines

D A Carson, J Kaye, S Matsumoto, J E Seegmiller, L Thompson

Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell lines

D A Carson et al. Proc Natl Acad Sci U S A. 1979 May.

Abstract

Human malignant T cell lines have high levels of deoxyribonucleoside phosphorylating activity and low levels of deoxyribonucleotide dephosphorylating activity. When incubated with deoxyadenosine or thymidine, the malignant T cell lines rapidly accumulate toxic concentrations of dATP and dTTP, respectively. This unusual pattern of deoxyribonucleotide metabolism renders the malignant T cells especially vulnerable to the toxic effects of deoxyribonucleosides and related analogues.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 1977 Dec;74(12):5677-81 - PubMed
    1. J Clin Invest. 1978 May;61(5):1405-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1978 Oct;75(10):5011-4 - PubMed
    1. J Clin Invest. 1978 Oct;62(4):884-7 - PubMed
    1. J Immunol. 1978 Nov;121(5):1726-31 - PubMed

Publication types

LinkOut - more resources