Undernutrition, Host Immunity and Vulnerability to Infection Among Young Children

Agnes Gwela^{1

2}, Ezekiel Mupere^{1

3}, James A Berkley^{1

2

4}, Christina Lancioni^{1

5}

Affiliations

¹ From the The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi.
² KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
³ Department of Pediatrics, Makerere University, Kampala, Uganda.
⁴ Centre for Tropical Medicine & Global Health, University of Oxford, Oxford, United Kingdom.
⁵ Department of Pediatrics, Oregon Health and Science University, Portland, Oregon.

Review

Agnes Gwela et al. Pediatr Infect Dis J. 2019 Aug.

. 2019 Aug;38(8):e175-e177.

doi: 10.1097/INF.0000000000002363.

Agnes Gwela^{1

2}, Ezekiel Mupere^{1

3}, James A Berkley^{1

2

4}, Christina Lancioni^{1

5}

¹ From the The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi.
² KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
³ Department of Pediatrics, Makerere University, Kampala, Uganda.
⁴ Centre for Tropical Medicine & Global Health, University of Oxford, Oxford, United Kingdom.
⁵ Department of Pediatrics, Oregon Health and Science University, Portland, Oregon.

No abstract available

Conflict of interest statement

The authors have no conflicts of interest to disclose.

1. Owino V, Ahmed T, Freemark M, et al. Environmental enteric dysfunction and growth failure/stunting in global child health. Pediatrics. 2016;138:e20160641. - PubMed
1. Palmer CD, Romero-Tejeda M, Sirignano M, et al. Naturally occurring subclinical endotoxemia in humans alters adaptive and innate immune functions through reduced MAPK and increased STAT1 phosphorylation. J Immunol. 2016;196:668–677. - PMC - PubMed
1. Bourke CD, Berkley JA, Prendergast AJ. Immune dysfunction as a cause and consequence of malnutrition. Trends Immunol. 2016;37:386–398. - PMC - PubMed
1. Subramanian S, Huq S, Yatsunenko T, et al. Persistent gut microbiota immaturity in malnourished Bangladeshi children. Nature. 2014;510:417–421. - PMC - PubMed
1. Smith MI, Yatsunenko T, Manary MJ, et al. Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. Science. 2013;339:548–54. - PMC - PubMed