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Review
. 2019 Jul;51(7):470-482.
doi: 10.1055/a-0926-3618. Epub 2019 Jul 15.

Precision Surgery for Pheochromocytomas and Paragangliomas

Douglas Wiseman  1 , Mustapha El Lakis  1 , Naris Nilubol  1
Affiliations
Review

Precision Surgery for Pheochromocytomas and Paragangliomas

Douglas Wiseman et al. Horm Metab Res. 2019 Jul.

Abstract

Since Felix Fränkel's account of pheochromocytoma in 1886, great discoveries and vast advancements in the diagnosis, genetics, anatomical and functional imaging techniques, and surgical management of pheochromcytoma and paraganglioma (P-PGL) have been made. The improved insight in the pathophysiology of P-PGL and more accurate detection methods enable physicians to tailor the treatment plan to an individual based on the genetic profile and tumor behavior. This review will cover briefly the clinical features, diagnosis, genetic mutations, and imaging modalities that are used to guide current surgical management of these rare and interesting endocrinopathies.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Computed tomography images a and b and magnetic resonance images c and d of pheochromocytoma a and c and paraganglioma b and d. α: Pheochromocytoma, arrows: Paraganglioma.
Fig. 2
Fig. 2
18F-FDOPA PET/CT a and 68Ga-DOTATATE PET/CT b in patients with SDHB germline mutation and left pheochromocytoma and right neck and intra-abdominal paragangliomas.
See this image and copyright information in PMC

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References

    1. Chen H, Sippel RS, O’Dorisio MS et al. The North American Neuroendocrine Tumor Society consensus guideline for the diagnosis and management of neuroendocrine tumors: Pheochromocytoma, paraganglioma, and medullary thyroid cancer. Pancreas 2010; 39: 775–783 - PMC - PubMed
    1. Lenders JW, Duh QY, Eisenhofer G et al. Pheochromocytoma and paraganglioma: An endocrine society clinical practice guideline. J Clin Endocrinol Metab 2014; 99: 1915–1942 - PubMed
    1. Fränkel F Ein Fall von doppelseitigem, völlig latent verlaufenen Nebennieren tumor und gleichzeitiger Nephritis mit Veränderungen am Circulationsapparat und Retinitis. Arch Pathol Anatom Physiol Klin Med 1886; 103: 244–263
    1. Bausch B, Tischler AS, Schmid KW et al. Max Schottelius: Pioneer in Pheochromocytoma. J Endocr Soc 2017; 1: 957–964 - PMC - PubMed
    1. Moore B On the chromogen and on the active physiological substance of the suprarenal gland. J Physiol 1897; 21: 382–389 - PMC - PubMed

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