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. 2019 Oct 11;5(10):1708-1717.
doi: 10.1021/acsinfecdis.9b00070. Epub 2019 Aug 5.

Efficient Blocking of Enterovirus 71 Infection by Heparan Sulfate Analogues Acting as Decoy Receptors

Daniel F Earley  1 , Benjamin Bailly  1 , Andrea Maggioni  1 , Avinash R Kundur  2 , Robin J Thomson  1 , Chih-Wei Chang  1 , Mark von Itzstein  1
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Efficient Blocking of Enterovirus 71 Infection by Heparan Sulfate Analogues Acting as Decoy Receptors

Daniel F Earley et al. ACS Infect Dis. .

Abstract

Enterovirus 71 (EV71) is a major etiological agent of hand, foot, and mouth disease, for which there is no antiviral therapy. We have developed densely sulfated disaccharide heparan sulfate (HS) analogues that are potent small molecule inhibitors of EV71 infection, binding to the viral capsid and acting as decoy receptors to block early events of virus replication. The simplified structures, more potent than defined HS disaccharides and with no significant anticoagulant activity, offer promise as anti-EV71 agents.

Keywords: HS analogue; binding inhibitor; enterovirus 71(EV71); hand, foot, and mouth disease (HFMD); heparan sulfate; sulfation.

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