Consequences of donor-derived passengers (pathogens, cells, biological molecules and proteins) on clinical outcomes

Abstract

It is recognized that donor factors contribute to lung transplant outcomes. Recent observations and studies have started to elucidate potential mechanisms behind explaining these observations. This perspective piece summarizes evolving lung transplant literature on the subject, focusing on donor "passenger" organisms, cells, hormones, and proteins transferred to the recipient. Many extrinsic and intrinsic donor features or properties have important consequences for subsequent allograft function in the recipient. Potentially, a better understanding of these features may provide useful novel therapeutic targets to enhance allograft outcomes.

Keywords: ex-vivo lung perfusion; immunology; lung transplantation; microbiome; passenger lymphocyte syndrome.