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Review
. 2019 Oct:139:56-61.
doi: 10.1016/j.radonc.2019.06.030. Epub 2019 Jul 12.

Ultra high dose rate Synchrotron Microbeam Radiation Therapy. Preclinical evidence in view of a clinical transfer

Laura Eling  1 , Audrey Bouchet  1 , Christian Nemoz  2 , Valentin Djonov  3 , Jacques Balosso  4 , Jean Laissue  5 , Elke Bräuer-Krisch  2 , Jean Francois Adam  1 , Raphael Serduc  6
Affiliations
Review

Ultra high dose rate Synchrotron Microbeam Radiation Therapy. Preclinical evidence in view of a clinical transfer

Laura Eling et al. Radiother Oncol. 2019 Oct.

Abstract

This paper reviews the current state of the art of an emerging form of radiosurgery dedicated to brain tumour treatment and which operates at very high dose rate (kGy·s-1). Microbeam Radiation Therapy uses synchrotron-generated X-rays which triggered normal tissue sparing partially mediated by FLASH effect.

Keywords: Brain tumours responses; High dose rate; Normal tissue sparing; Synchrotron Microbeam Radiation Therapy.

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