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Case Reports
. 2019 Jul 15;12(7):e229141.
doi: 10.1136/bcr-2018-229141.

McCune Albright syndrome: an endocrine medley

Remya Rajan  1 , Kripa Elizabeth Cherian  1 , Hesarghatta Shyamsunder Asha  1 , Thomas Vizhalil Paul  1
Affiliations
Case Reports

McCune Albright syndrome: an endocrine medley

Remya Rajan et al. BMJ Case Rep. .

Abstract

McCune Albright syndromeis a rare disorder that presents with multiple endocrine abnormalities. We report the case of a 24-year-old woman who presented with right lower limb pain, with no preceding trauma or fracture. On examination she was noted to have coarsened facial features, acral enlargement, bitemporal hemianopia, galactorrhoea and multiple café-au-lait macules. She gave history of precocious puberty, having attained menarche at 7 years of age. Biochemical investigations revealed hyperprolactinaemia, with unsuppressed growth hormone levels following a glucose load and subclinical hyperthyroidism. Technetium-99m methylene diphosphonate bone scan showed polyostotic fibrous dysplasia, MRI of the brain showed a pituitary macroadenoma. Thus she was diagnosed to have McCune Albright syndrome with multiple endocrine manifestations. She was treated with parenteral zoledronate for her bony lesions and initiated on cabergoline for plurihormonal pituitary macroadenoma. She is planned to be on close follow-up to assess for clinical improvement and appearance of other manifestations.

Keywords: calcium and bone; pituitary disorders; thyroid disease.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Café-au-lait macules with irregular borders.
Figure 2
Figure 2
Acral enlargement.
Figure 3
Figure 3
Loss of trabeculae, lytic lesions, ground-glass appearance.
Figure 4
Figure 4
Technetium- 99m methylene diphosponate bone scan showing polyostotic fibrous dysplasia.
Figure 5
Figure 5
I-131 uptake scan showing two functioning nodules in right lobe and suppressed left lobe.
Figure 6
Figure 6
MRI brain showing pituitary macroadenoma.
See this image and copyright information in PMC

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