Mucosal-associated invariant T cells and disease

Amine Toubal^{1

2

3}, Isabelle Nel^{1

2

3}, Sophie Lotersztajn^{2

3

4}, Agnès Lehuen^{5

6

7}

Affiliations

¹ Institut Cochin, Centre National de la Recherche Scientifique (CNRS) UMR8104, INSERM U1016, Paris, France.
² Université de Paris, Paris, France.
³ Laboratoire d'Excellence Inflamex, Paris, France.
⁴ INSERM UMR1149, Centre de Recherche sur l'Inflammation, Paris, France.
⁵ Institut Cochin, Centre National de la Recherche Scientifique (CNRS) UMR8104, INSERM U1016, Paris, France. agnes.lehuen@inserm.fr.
⁶ Université de Paris, Paris, France. agnes.lehuen@inserm.fr.
⁷ Laboratoire d'Excellence Inflamex, Paris, France. agnes.lehuen@inserm.fr.

PMID: 31308521
DOI: 10.1038/s41577-019-0191-y

Review

Mucosal-associated invariant T cells and disease

Amine Toubal et al. Nat Rev Immunol. 2019 Oct.

. 2019 Oct;19(10):643-657.

doi: 10.1038/s41577-019-0191-y.

Authors

Amine Toubal^{1

2

3}, Isabelle Nel^{1

2

3}, Sophie Lotersztajn^{2

3

4}, Agnès Lehuen^{5

6

7}

Affiliations

¹ Institut Cochin, Centre National de la Recherche Scientifique (CNRS) UMR8104, INSERM U1016, Paris, France.
² Université de Paris, Paris, France.
³ Laboratoire d'Excellence Inflamex, Paris, France.
⁴ INSERM UMR1149, Centre de Recherche sur l'Inflammation, Paris, France.
⁵ Institut Cochin, Centre National de la Recherche Scientifique (CNRS) UMR8104, INSERM U1016, Paris, France. agnes.lehuen@inserm.fr.
⁶ Université de Paris, Paris, France. agnes.lehuen@inserm.fr.
⁷ Laboratoire d'Excellence Inflamex, Paris, France. agnes.lehuen@inserm.fr.

PMID: 31308521
DOI: 10.1038/s41577-019-0191-y

Abstract

Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate and adaptive immunity. They are activated by conserved bacterial ligands derived from vitamin B biosynthesis and have important roles in defence against bacterial and viral infections. However, they can also have various deleterious and protective functions in autoimmune, inflammatory and metabolic diseases. MAIT cell involvement in a large spectrum of pathological conditions makes them attractive targets for potential therapeutic approaches.

PubMed Disclaimer

Cited by

Mucosal-Associated Invariant T Cells Are Involved in Acute Ischemic Stroke by Regulating Neuroinflammation.
Nakajima S, Tanaka R, Yamashiro K, Chiba A, Noto D, Inaba T, Kurita N, Miyamoto N, Kuroki T, Shimura H, Ueno Y, Urabe T, Miyake S, Hattori N. Nakajima S, et al. J Am Heart Assoc. 2021 Apr 6;10(7):e018803. doi: 10.1161/JAHA.120.018803. Epub 2021 Mar 18. J Am Heart Assoc. 2021. PMID: 33733818 Free PMC article.
Mucosal-associated invariant T cells contribute to suppression of inflammatory myeloid cells in immune-mediated kidney disease.
Gnirck AC, Philipp MS, Waterhölter A, Wunderlich M, Shaikh N, Adamiak V, Henneken L, Kautz T, Xiong T, Klaus D, Tomczyk P, Al-Bahra MM, Menche D, Walkenhorst M, Lantz O, Willing A, Friese MA, Huber TB, Krebs CF, Panzer U, Kurts C, Turner JE. Gnirck AC, et al. Nat Commun. 2023 Nov 15;14(1):7372. doi: 10.1038/s41467-023-43269-0. Nat Commun. 2023. PMID: 37968302 Free PMC article.
Human unconventional T cells in Plasmodium falciparum infection.
Schmaler M, Orlova-Fink N, Rutishauser T, Abdulla S, Daubenberger C. Schmaler M, et al. Semin Immunopathol. 2020 Jun;42(3):265-277. doi: 10.1007/s00281-020-00791-3. Epub 2020 Feb 19. Semin Immunopathol. 2020. PMID: 32076813 Free PMC article. Review.
Human Tumor-Infiltrating MAIT Cells Display Hallmarks of Bacterial Antigen Recognition in Colorectal Cancer.
Li S, Simoni Y, Becht E, Loh CY, Li N, Lachance D, Koo SL, Lim TP, Tan EKW, Mathew R, Nguyen A, Golovato J, Berkson JD, Prlic M, Lee B, Minot SS, Nagarajan N, Dey N, Tan DSW, Tan IB, Newell EW. Li S, et al. Cell Rep Med. 2020 Jun 23;1(3):100039. doi: 10.1016/j.xcrm.2020.100039. eCollection 2020 Jun 23. Cell Rep Med. 2020. PMID: 33205061 Free PMC article.
Beyond the Injury: How Does Smoking Impair Stem Cell-Mediated Repair Mechanisms? A Dual Review of Smoking-Induced Stem Cell Damage and Stem Cell-Based Therapeutic Applications.
Karam M, Aqel S, Haider MZ, Fathima A, Charafedine A, Daher MA, Shaito A, El-Sabban M, Saliba J. Karam M, et al. Stem Cell Rev Rep. 2025 Jun;21(5):1311-1330. doi: 10.1007/s12015-025-10886-9. Epub 2025 Apr 25. Stem Cell Rev Rep. 2025. PMID: 40279029 Review.

See all "Cited by" articles

References

1. Porcelli, S., Yockey, C. E., Brenner, M. B. & Balk, S. P. Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain. J. Exp. Med. 178, 1–16 (1993). - PubMed
1. Tilloy, F. et al. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals. J. Exp. Med. 189, 1907–1921 (1999). - PubMed - PMC
1. Treiner, E. et al. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature 422, 164–169 (2003). This study describes for the first time MAIT cell restriction to the non-polymorphic MHC class I-like protein MR1. - PubMed
1. Martin, E. et al. Stepwise development of MAIT cells in mouse and human. PLOS Biol. 7, e54 (2009). - PubMed
1. Gold, M. C. et al. Human mucosal associated invariant T cells detect bacterially infected cells. PLOS Biol. 8, e1000407 (2010). - PubMed - PMC

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Nature Publishing Group
Other Literature Sources
- The Lens - Patent Citations Database

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Mucosal-associated invariant T cells and disease

Affiliations

Mucosal-associated invariant T cells and disease

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources