Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Jul 1;5(2):2055116919861248.
doi: 10.1177/2055116919861248. eCollection 2019 Jul-Dec.

Hyperplastic and fibrosing gastropathy resembling Ménétrier disease in a cat

Emi N Barker  1 , Andrew S Holdsworth  2 , Angie Hibbert  1 , Peter J Brown  3 , Nicolette J Hayward  4
Affiliations
Case Reports

Hyperplastic and fibrosing gastropathy resembling Ménétrier disease in a cat

Emi N Barker et al. JFMS Open Rep. .

Abstract

Case summary: A 3.5-year-old domestic shorthair cat presented with a 6 month history of weight loss and polyphagia. Clinical examination revealed a markedly reduced body condition score (2/9) and a quiet demeanour. Laboratory abnormalities comprised a mild non-regenerative anaemia, stress leukogram, hypoproteinaemia due to hypoalbuminaemia, azotaemia, hypokalaemia, total hypocalcaemia and sub-maximally concentrated urine (specific gravity 1.020). Abdominal ultrasonography revealed marked thickening of the gastric mucosa within the fundus, body and pylorus; the most dorsal portion of the fundus was spared. The thickened mucosa contained multiple small, anechoic cyst-like structures. The gastric submucosa, muscularis and serosa appeared normal. Histopathology, performed on a full-thickness gastric biopsy, revealed mucosal hypertrophy and markedly dilated gastric glands in areas; not all gastric glands were affected, with some appearing normal or atrophic. Focal interstitial fibrosis was present in some areas. The findings of hypoproteinaemia, gastric ultrasonographic changes and histopathology results share several similarities to those reported with Ménétrier disease.

Relevance and novel information: Ménétrier disease is a rare condition of the stomach in humans. A similar condition, giant hypertrophic gastritis (or Ménétrier-like disease), has also been described rarely in dogs. To our knowledge, Ménétrier-like disease has not been previously described cats. This case shares features of Ménétrier-like disease, raising the suspicion of a similar aetiopathogenesis.

Keywords: Gastropathy; giant hypertrophic gastritis; stomach; ultrasound.

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1
Figure 1
Ultrasonographic images of the stomach in the (a) axial plane through the body of the stomach, and (b) longitudinal plane. Note the marked thickening of the mucosa (up to 14 mm; normal overall gastric wall thickness 1.7–3.6 mm), which contains multiple small (2–3 mm diameter), rounded anechoic cyst-like structures (selection indicated by arrows). The normal layered appearance of the muscularis and serosa is present. The stomach is empty
Figure 2
Figure 2
Intraoperative photograph showing the irregular, cerebriform-like appearance of the gastric serosal surface. Courtesy of Ivan Doran
Figure 3
Figure 3
Histological section of gastric mucosa showing variably dilated gastric glands, lined by poorly differentiated cuboidal cells. There is also some interstitial fibrosis (arrow). Haematoxylin and eosin
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Coffey RJ, Jr, Tanksley J. Pierre Ménétrier and his disease. Trans Am Clin Climatol Assoc 2012; 123: 126–133. - PMC - PubMed
    1. Famularo G, Sajeva MR, Gasbarrone L. Beyond gastritis and before cancer: the strange case of Ménétrier’s disease. Intern Emerg Med 2011; 6: 369–371. - PubMed
    1. Lambrecht NW. Menetrier’s disease of the stomach: a clinical challenge. Curr Gastroenterol Rep 2011; 13: 513–517. - PubMed
    1. Rallis TS, Patsikas MN, Mylonakis ME, et al. Giant hypertrophic gastritis (Ménétrier’s-like disease) in an Old English sheepdog. J Am Anim Hosp Assoc 2007; 43: 122–127. - PubMed
    1. Vaughn DP, Syrcle J, Cooley J. Canine giant hypertrophic gastritis treated successfully with partial gastrectomy. J Am Anim Hosp Assoc 2014; 50: 62–66. - PubMed

Publication types

LinkOut - more resources