Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2019 Dec;187(5):559-562.
doi: 10.1111/bjh.16099. Epub 2019 Jul 15.

Langerhans cell histiocytosis: progress and controversies

Oussama Abla  1 , Barrett Rollins  2 , Stephan Ladisch  3
Affiliations
Editorial

Langerhans cell histiocytosis: progress and controversies

Oussama Abla et al. Br J Haematol. 2019 Dec.
No abstract available

Keywords: braf-V600E; clinical trials; histiocytosis; stratification.

PubMed Disclaimer

References

    1. Abla, O., Weitzman, S., Minkov, M., McClain, K.L., Visser, J., Filipovich, A. & Grois, N. (2009) Diabetes insipidus in Langerhans cell histiocytosis: when is treatment indicated? Pediatric Blood & Cancer, 52, 555-556.
    1. Badalian-Very, G., Vergilio, J.A., Degar, B.A., MacConaill, L.E., Brandner, B., Calicchio, M.L., Kuo, F.C., Ligon, A.H., Stevenson, K.E., Kehoe, S.M., Garraway, L.A., Hahn, W.C., Meyerson, M., Fleming, M.D. & Rollins, B.J. (2010) Recurrent BRAF mutations in Langerhans cell histiocytosis. Blood, 116, 1919-1923.
    1. Bhatia, A., Ulaner, G., Rampal, R., Hyman, D.M., Abdel-Wahab, O., Durham, B.H.3, Dogan, A., Ozkaya, N., Lacouture, M.E., Hajdenberg, J., Ganzel, C. & Diamond, E.L. (2018) Single-agent dabrafenib for BRAFV600E mutatedhistiocytosis. Haematologica, 103, e177-e180.
    1. Brown, N.A., Furtado, L.V., Betz, B.L., Kiel, M.J., Weigelin, H.C., Lim, M.S. & Elenitoba-Johnson, K.S. (2014) High prevalence of somatic MAP2K1 mutations in BRAF V600E-negative Langerhans cell histiocytosis. Blood, 124, 1655-1658.
    1. Chakraborty, R., Hampton, O.A., Shen, X., Simko, S.J., Shih, A., Abhyankar, H., Lim, K.P., Covington, K.R., Trevino, L., Dewal, N., Muzny, D.M., Doddapaneni, H., Hu, J., Wang, L., Lupo, P.J., Hicks, M.J., Bonilla, D.L., Dwyer, K.C., Berres, M.L., Poulikakos, P.I., Merad, M., McClain, K.L., Wheeler, D.A., Allen, C.E. & Parsons, D.W. (2014) Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis. Blood, 124, 3007-3015.

Publication types

MeSH terms

LinkOut - more resources