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Case Reports
. 2019 Sep;36(5):672-676.
doi: 10.1111/pde.13884. Epub 2019 Jul 16.

Disseminated Bacille Calmette-Guérin infection in a patient with severe combined immunodeficiency caused by JAK3 gene mutation

Meiyun Li  1 , Zhuo Chen  1 , Yunlu Zhu  2 , Ji Chen  1
Affiliations
Case Reports

Disseminated Bacille Calmette-Guérin infection in a patient with severe combined immunodeficiency caused by JAK3 gene mutation

Meiyun Li et al. Pediatr Dermatol. 2019 Sep.

Abstract

Bacille Calmette-Guérin (BCG), a live attenuated vaccine prepared using Mycobacterium bovis, can prevent tuberculosis in children and is routinely administered to infants in China and many other countries. A serious complication following vaccination is disseminated BCG infection. The risk is greatly increased in patients with severe combined immunodeficiency disease (SCID), a syndrome characterized by deficiency of both humoral and cellular immunity. We report a case of disseminated BCG infection in an infant with SCID caused by two novel janus kinase 3 (JAK3) gene mutations.

Keywords: JAK3; Bacille Calmette-Guerin (BCG); mutation; severe combined immunodeficiency; vaccination.

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References

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