Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Apr 25;48(2):214-218.
doi: 10.3785/j.issn.1008-9292.2019.04.14.

[Research progress on miR-21 in heart diseases]

[Article in Chinese]
Kun Yang  1 , Xiaosheng Hu  1
Affiliations
Review

[Research progress on miR-21 in heart diseases]

[Article in Chinese]
Kun Yang et al. Zhejiang Da Xue Xue Bao Yi Xue Ban. .

Abstract
in English, Chinese

Pathological processes such as myocardial apoptosis, cardiac hypertrophy, myocardial fibrosis, and cardiac electrical remodeling are involved in the development and progression of most cardiac diseases. MicroRNA-21 (miR-21) has been found to play an important role in heart diseases as a novel type of endogenous regulators, which can inhibit cardiomyocyte apoptosis, improve hypertension and cardiac hypertrophy, promote myocardial fibrosis and atrial electrical remodeling. In this review, we summarize the research progress on the function of miR-21 in heart diseases and its mechanism, and discuss its potential application in diagnosis and treatment of heart diseases.

心肌凋亡、心脏肥大、心肌纤维化和心房电重构等病理过程参与了绝大部分心脏疾病的发生和发展，阐明其中病理机制有助于心脏疾病的诊断和治疗。近年研究发现，微小RNA-21（miR-21）作为一类新型内源性调节因子，具有抑制心肌细胞凋亡、改善高血压和心脏肥大、促进心肌纤维化进展、促进心房电重构等作用。本文就miR-21在心脏疾病中的作用和机制研究进展进行综述，并初步探讨miRNA作为心脏疾病临床诊断标志物和治疗靶点的应用前景。

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. LI C J, CHEN C S, YIANG G T, et al. Advanced evolution of pathogenesis concepts in cardiomyopathies[J/OL]. J Clin Med, 2019, 8(4): pii: E520. - PMC - PubMed
    1. MARTINEZ S R, GAY M S, ZHANG L. Epigenetic mechanisms in heart development and disease. Drug Discov Today. 2015;20(7):799–811. doi: 10.1016/j.drudis.2014.12.018. [MARTINEZ S R, GAY M S, ZHANG L. Epigenetic mechanisms in heart development and disease[J]. Drug Discov Today, 2015, 20(7):799-811.] - DOI - PMC - PubMed
    1. WANG F, JIA J, RODRIGUES B. Autophagy, metabolic disease, and pathogenesis of heart dysfunction. Can J Cardiol. 2017;33(7):850–859. doi: 10.1016/j.cjca.2017.01.002. [WANG F, JIA J, RODRIGUES B. Autophagy, metabolic disease, and pathogenesis of heart dysfunction[J]. Can J Cardiol, 2017, 33(7):850-859.] - DOI - PubMed
    1. CHISTIAKOV D A, OREKHOV A N, BOBRYSHEV Y V. Cardiac-specific miRNA in cardiogenesis, heart function, and cardiac pathology (with focus on myocardial infarction) J Mol Cell Cardiol. 2016;94:107–121. doi: 10.1016/j.yjmcc.2016.03.015. [CHISTIAKOV D A, OREKHOV A N, BOBRYSHEV Y V. Cardiac-specific miRNA in cardiogenesis, heart function, and cardiac pathology (with focus on myocardial infarction)[J]. J Mol Cell Cardiol, 2016, 94:107-121.] - DOI - PubMed
    1. VACANTE F, DENBY L, SLUIMER J C, et al. The function of miR-143, miR-145 and the MiR-143 host gene in cardiovascular development and disease. Vascul Pharmacol. 2019;112:24–30. doi: 10.1016/j.vph.2018.11.006. [VACANTE F, DENBY L, SLUIMER J C, et al. The function of miR-143, miR-145 and the MiR-143 host gene in cardiovascular development and disease[J]. Vascul Pharmacol, 2019, 112:24-30.] - DOI - PMC - PubMed