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. 2019 Oct;33(10):e13669.
doi: 10.1111/ctr.13669. Epub 2019 Sep 30.

Post-transplant malignancy in solid organ transplant recipients in Ireland, The Irish Transplant Cancer Group

James Paul O'Neill  1   2 , Donal J Sexton  3 , Eamonn O'Leary  4 , Patrick O'Kelly  3 , Susan Murray  3 , Sandra Deady  4 , Fergus Daly  3 , Yvonne Williams  3 , Ben Dean  3 , Conall Fitzgerald  1 , Aizuri Murad  5 , Nazish Mansoor  5 , Jim O O'Neill  6 , Jim Egan  7 , Diarmaid D Houlihan  8 , P Aiden McCormick  8 , Patrick G Morris  2   9 , Siona Ni Raghallaigh  10 , Dilly Little  3 , Fergal J Moloney  5 , Peter J Conlon  2   3
Affiliations

Post-transplant malignancy in solid organ transplant recipients in Ireland, The Irish Transplant Cancer Group

James Paul O'Neill et al. Clin Transplant. 2019 Oct.

Abstract

Objective: Solid organ transplant recipients are at increased risk of cancer compared to the general population. To date, this risk in Ireland has not been investigated. We conducted a national registry study of cancer incidence following solid organ transplantation.

Methods: National centers for solid organ transplantation supplied their respective registry databases to cross-reference with episodes of malignancy from the National Cancer Registry Ireland (NCRI) between 1994 and 2014. Standardized incidence of cancer post-transplant was compared to the general population by means of standardized incidence ratios (SIRs), and between solid organ transplant types by incidence rate ratios.

Results: A total of 3346 solid organ transplant recipients were included in this study. Kidney transplant recipients constituted the majority of participants (71.2%), followed by liver (16.8%), heart (6.4%), and lung (5.6%) transplants. The most common cancers within the composite of all transplant recipients included the following (SIR [95% CI]): squamous and basal cell carcinoma (20.05 [17.97, 22.31] and 7.16 [6.43, 7.96], respectively), non-Hodgkin lymphoma (6.23 [4.26, 8.59]), and renal cell carcinoma (3.36 [1.96, 5.38]).

Conclusions: This study reports the incidence of cancer following solid organ transplantation in Ireland. These results have significant national policy implications for surveillance, and early diagnosis in this patient group.

Keywords: cancer; incidence; transplant.

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References

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