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Review
. 2020 Apr;49(4):294-304.
doi: 10.1111/jop.12924. Epub 2019 Jul 16.

Oral submucous fibrosis in Asian countries

Qian Peng  1   2 , Hongyuan Li  1   2 , Juan Chen  1   2 , Yuehong Wang  1   2 , Zhangui Tang  1   2
Affiliations
Review

Oral submucous fibrosis in Asian countries

Qian Peng et al. J Oral Pathol Med. 2020 Apr.

Abstract

Oral submucous fibrosis (OSF) is a chronic, insidious, and progressive oral mucosal disease that affects entire oral cavity and sometimes pharynx. This oral potentially malignant disorder has a high rate of malignant transformation (7%-30%) to oral squamous cell carcinoma (OSCC), posing global problems for public health. Due to enormous efforts dedicated to this disease in the past decades, there have been significant advances in identification of its etiology and pathogenesis as well as development of corresponding therapeutic approaches, in spite of several challenges. This study reviewed the existing literature concerning OSF in Asian countries, encompassing its etiology, histopathology, pathogenesis, clinical manifestations, diagnosis and differential diagnosis, and treatments. For improving treatment of OSF, the multifactorial etiology analysis, incorporation of effective molecular pathways, cytokines and cells for mechanism illustration, and integration of multidisciplinary modalities were also expounded to guide future research and clinical practice.

Keywords: multifactorial etiology; oral submucous fibrosis; pathogenesis; treatment.

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References

REFERENCES

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