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Review
. 2020 Jan;45(1):3-5.
doi: 10.1038/s41386-019-0465-x. Epub 2019 Jul 16.

Drugs, sleep, and the addicted brain

Rita J Valentino  1 , Nora D Volkow  2
Affiliations
Review

Drugs, sleep, and the addicted brain

Rita J Valentino et al. Neuropsychopharmacology. 2020 Jan.
No abstract available

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Figures

Fig. 1
Fig. 1
Schematic depicting efferent projections of lateral hypothalamic orexin neurons. The orexin system is positioned to influence cognitive function, arousal, and reward. Orexin neurons have broad forebrain projections. Cortical projections may modulate cognitive aspects of substance use behavior such as decision-making. In addition, they project to arousal-related nuclei, including the locus coeruleus (LC), which expresses norepinephrine (NE), dorsal raphe nucleus (DRN), which expresses serotonin (5-HT), lateral dorsotegmental nucleus (LDT), which expresses acetylcholine (ACh), tuberomammillary nucleus (TMN), which expresses histamine (HA), and nucleus basalis of Meynert (NBM), which expresses ACh. These nuclei in turn have diffuse projections throughout the forebrain. Orexin neuronal projections to the ventral tegmental area (VTA) and nucleus accumbens (NAc) are poised to modulate reward and to make rewarding stimuli arousing
See this image and copyright information in PMC

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