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Review
. 2019 Jul 15;55(7):373.
doi: 10.3390/medicina55070373.

Hematologic Manifestations in Celiac Disease-A Practical Review

Daniel Vasile Balaban  1   2 , Alina Popp  3   4   5 , Florentina Ionita Radu  6   7 , Mariana Jinga  3   6
Affiliations
Review

Hematologic Manifestations in Celiac Disease-A Practical Review

Daniel Vasile Balaban et al. Medicina (Kaunas). .

Abstract

Celiac disease (CD) is a systemic autoimmune disease driven by gluten-ingestion in genetically predisposed individuals. Although it primarily affects the small bowel, CD can also involve other organs and manifest as an extraintestinal disease. Among the extraintestinal features of CD, hematologic ones are rather frequent and consist of anemia, thrombocytosis (thrombocytopenia also, but rare), thrombotic or hemorrhagic events, IgA deficiency, hyposplenism, and lymphoma. These hematologic alterations can be the sole manifestation of the disease and should prompt for CD testing in a suggestive clinical scenario. Recognition of these atypical, extraintestinal presentations, including hematologic ones, could represent a great opportunity to increase the diagnostic rate of CD, which is currently one of the most underdiagnosed chronic digestive disorders worldwide. In this review, we summarize recent evidence regarding the hematological manifestations of CD, with focus on practical recommendations for clinicians.

Keywords: IgA deficiency; anemia; celiac disease; lymphoma.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Gujral N., Freeman H.J., Thomson A.B. Celiac disease: Prevalence, diagnosis, pathogenesis and treatment. World J. Gastroenterol. 2012;18:6036–6059. doi: 10.3748/wjg.v18.i42.6036. - DOI - PMC - PubMed
    1. Singh P., Arora A., Strand T.A., Leffler D.A., Catassi C., Green P.H., Kelly C.P., Ahuja V., Makharia G.K. Global prevalence of celiac disease: Systematic review and meta-analysis. Clin. Gastroenterol. Hepatol. 2018;16:823–836.e2. doi: 10.1016/j.cgh.2017.06.037. - DOI - PubMed
    1. Leffler D.A., Green P.H., Fasano A. Extraintestinal manifestations of coeliac disease. Nat. Rev. Gastroenterol. Hepatol. 2015;12:561–571. doi: 10.1038/nrgastro.2015.131. - DOI - PubMed
    1. Reunala T., Salmi T.T., Hervonen K., Kaukinen K., Collin P. Dermatitis Herpetiformis: A Common Extraintestinal Manifestation of Coeliac Disease. Nutrients. 2018;10:602. doi: 10.3390/nu10050602. - DOI - PMC - PubMed
    1. Pinto-Sanchez M.I., Bercik P., Verdu E.F., Bai J.C. Extraintestinal manifestations of celiac disease. Dig. Dis. 2015;33:147–154. doi: 10.1159/000369541. - DOI - PubMed

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