Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jul 15;9(3):77.
doi: 10.3390/diagnostics9030077.

Prevalence of Oral Lesions and Correlation with Intestinal Symptoms of Inflammatory Bowel Disease: A Systematic Review

Dorina Lauritano  1 , Elisa Boccalari  2 , Dario Di Stasio  3 , Fedora Della Vella  4 , Francesco Carinci  5 , Alberta Lucchese  3 , Massimo Petruzzi  4
Affiliations
Review

Prevalence of Oral Lesions and Correlation with Intestinal Symptoms of Inflammatory Bowel Disease: A Systematic Review

Dorina Lauritano et al. Diagnostics (Basel). .

Abstract

Background: Extra-intestinal manifestations of inflammatory bowel disease (IBD) are widely studied. Oral manifestations are manifold, miscellaneous, and hardly detected by general practitioners and gastroenterologists.

Objectives: The main purpose of this systematic review is to find all the possible correlations between inflammatory bowel disease and the oral cavity in order to underline the importance of multidisciplinary cooperation with dental care providers, and to secure better treatments for patients.

Materials and methods: Articles were searched up to June 2019 through Ebsco's, Google Scholar, and PubMed databases. The search terms included IBD, oral manifestations of inflammatory bowel disease, oral manifestations of Crohn's disease or Ulcerative colitis, an extra-intestinal manifestation of IBD, oral Crohn's disease, and paediatric inflammatory bowel disease.

Discussion: The prevalence of the oral manifestation of IBD ranges from 0.7% to 37% in adults and from about 7% to 23% in children. They can be divided into specific manifestations (cobblestoning mucosa, mucosal tags, cheilitis granulomatosa, pyostomatitis vegetans) and nonspecific manifestations (halitosis, dysphagia, aphthous ulcerations, deep oral fissuring, cheilitis angularis, taste changes, lichen planus). Moreover, the link between IBD and the higher prevalence of dental caries and periodontitis have also been studied.

Conclusions: The presence of oral manifestations that precede or follow intestinal symptoms of IBD, must be taken into serious consideration from both gastroenterologists and dentists in order to allow for early diagnosis and improve patients' quality of life.

Keywords: Crohn’s disease; inflammatory bowel disease; oral manifestations; ulcerative colitis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Newcastle Ottawa scale modified for cross sectional studies.
Figure 2
Figure 2
PRISMA flow diagram.
Figure 3
Figure 3
Oral manifestations of IBD: apthous stomatis in the vestibular sulci.
Figure 4
Figure 4
Oral manifestation of IBD: lichen planus in the left buccal mucosa.
See this image and copyright information in PMC

References

    1. Habashneh R.A., Khader Y.S., Alhumouz M.K., Jadallah K., Ajlouni Y. The association between inflammatory bowel disease and periodontitis among Jordanians: A case-control study. J. Periodontal. Res. 2012;47:293–298. doi: 10.1111/j.1600-0765.2011.01431.x. - DOI - PubMed
    1. Greuter T., Bertoldo F., Rechner R., Straumann A., Biedermann L., Zeitz J., Misselwitz B., Scharl M., Rogler G., Safroneeva E., et al. Extraintestinal manifestations of pediatric inflammatory bowel disease: Prevalence, presentation and anti-TNF treatment. J. Pediatric. Gastroenterol. 2017;65:200–206. doi: 10.1097/MPG.0000000000001455. - DOI - PubMed
    1. Zippi M., Corrado C., Pica R., Avallone E.V., Cassieri C., De Nitto D., Paoluzi P., Vernia P. Extraintestinal manifestations in a large series of Italian inflammatory bowel disease patients. World. J. Gastroenterol. 2014;20:17463–17467. doi: 10.3748/wjg.v20.i46.17463. - DOI - PMC - PubMed
    1. Khouri J.M., Bohane T.D., Day A.S. Is orofacial granulomatosis in children a feature of Crohn’s disease? Acta. Paediatr. 2005;94:501–504. doi: 10.1111/j.1651-2227.2005.tb01925.x. - DOI - PubMed
    1. Jose F.A., Garnett E.A., Vittinghoff E., Ferry G.D., Winter H.S., Baldassano R.N., Kirschner B.S., Cohen S.A., Gold B.D., Abramson O., et al. Development of Extraintestinal Manifestations in Pediatric Patients with Inflammatory Bowel Disease. Inflamm. Bowel. Dis. 2009;151:63–68. doi: 10.1002/ibd.20604. - DOI - PMC - PubMed

LinkOut - more resources