Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jun 26;43(2):120-122.
doi: 10.1080/01658107.2018.1481106. eCollection 2019 Apr.

Diagnosis in a case total ophthalmoplegia - where time is life

Aditya Sethi  1 , Shikha Talwar Bassi  2 , Veena Noronha  3 , K Lily Therese  4
Affiliations

Diagnosis in a case total ophthalmoplegia - where time is life

Aditya Sethi et al. Neuroophthalmology. .

Abstract

Rhino-orbito-cerebral mucormycosis is a potentially fatal fungal infection seen in poorly controlled diabetics or immunocompromised patients who can present initially to an ophthalmologist, otorhinolaryngologist or a neurologist. The clinical presentation to an ophthalmologist may be that of painful ophthalmoplegia.The confirmation and further management of the infection requires an interdisciplinary approach. A timely diagnosis and intervention can be life-saving. This article depicts the typical fulminant course and diagnostic evaluation of rhino-orbito-cerebral mucormycosis.

Keywords: Painful ophthalmoplegia; diabetic; mucormycosis.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
External photo of the eyes depicting total ophthalmoplegia with a middilated pupil and mild redness in the  left eye.
Figure 2.
Figure 2.
A contrast enhanced magnetic resonance imaging (MRI) brain and orbit coronal (a,b,c) and axial (d) sections with the arrows pointing to the fungal granuloma in the superior orbital fissure and the cavernous sinus.
Figure 3.
Figure 3.
Fungal filaments as seen on fluorescence microscopy.
See this image and copyright information in PMC

References

    1. Mendoza L, Vilela R, Voelz K, Ibrahim AS, Voigt K, Lee SC.. Human fungal pathogens of mucorales and entomophthorales. Cold Spring Harb Perspect Med. 2015;5:4. doi:10.1101/cshperspect.a019562. - DOI - PMC - PubMed
    1. Shinde RV, Karande GS, Mohite ST, Patil SR. Rhino-orbital mucormycosis in diabetes mellitus. J Clin Diagn Res. 2013;7:1145–1147. - PMC - PubMed
    1. Jiang N, Zhao G, Yang S, et al. A retrospective analysis of eleven cases of invasive rhino-orbito-cerebral mucormycosis presented with orbital apex syndrome initially. BMC Ophthalmol. 2016;16:10. doi:10.1186/s12886-016-0189-1. - DOI - PMC - PubMed

LinkOut - more resources