Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jul 2;43(3):159-170.
doi: 10.1080/01658107.2019.1604763. eCollection 2019 Jun.

Varicella Zoster Virus in Giant Cell Arteritis: A Review of Current Medical Literature

Affiliations
Review

Varicella Zoster Virus in Giant Cell Arteritis: A Review of Current Medical Literature

Rochella A Ostrowski et al. Neuroophthalmology. .

Abstract

In recent years, the search for the cause of giant cell arteritis (GCA) has led investigators to look to varicella zoster virus (VZV) as the answer. In some ways, the nature of VZV infection makes it an attractive explanation for the pathology observed in GCA. However, studies to date yield a level of inconsistency that still leaves uncertainty as to whether VZV directly causes GCA, and positive findings have not been successfully reproduced.

Keywords: Giant cell arteritis; temporal artery biopsy; varicella zoster virus; vasculitis.

PubMed Disclaimer

References

    1. Poller DN, van Wyk Q, Jeffrey MJ.. The importance of skip lesions in temporal arteritis. J Clin Pathol. 2000;53:137–139. - PMC - PubMed
    1. Weyand C, Liao J, Goronzy J. The immunopathology of giant cell arteritis: diagnostic and therapeutic implications. J Neuroophthalmol. 2012;32(3):259–265. doi:10.1097/WNO.0b013e318268aa9b. - DOI - PMC - PubMed
    1. Nagel MA, Gilden D. Developments in varicella zoster virus vasculopathy. Curr Neurol Neurosci Rep. 2016; 16(12):doi: 10.1007/s11910-015-0614-5. - DOI - PMC - PubMed
    1. Ciccia F, Rizzo A, Ferrante A, et al. New insights into the pathogenesis of giant cell arteritis. Autoimmun Rev. 2017;16:675–683. doi:10.1016/j.autrev.2017.05.004. - DOI - PubMed
    1. Fukumoto S, Kinjo M, Hokamura K, Tanaka K. Subarachnoid hemorrhage and granulomatous angiitis of the basilar artery: demonstration of the varicella-zoster-virus in the basilar artery lesions. Stroke. 1986;17:1024–1028. - PubMed

LinkOut - more resources