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Review
. 2019 May 8;11(5):e4620.
doi: 10.7759/cureus.4620.

Recommendations for Anti-inflammatory Treatments in Alzheimer's Disease: A Comprehensive Review of the Literature

Muhammad Mohsin Ali  1 , Raza G Ghouri  1 , Armghan H Ans  2 , Arshia Akbar  3 , Ahmed Toheed  1
Affiliations
Review

Recommendations for Anti-inflammatory Treatments in Alzheimer's Disease: A Comprehensive Review of the Literature

Muhammad Mohsin Ali et al. Cureus. .

Abstract

Alzheimer's disease (AD) is the most common cause of dementia in elderly patients, affecting individuals older than 60 years. It is a complex degenerative brain disease characterized by progressive cognitive impairment. AD constitutes a major global health concern. A central role for inflammation has been implicated in the pathogenesis of AD. Despite the understanding of multiple molecular pathways in the pathophysiology of AD, novel treatment agents with a possible role in modifying the disease activity are still lacking. Our article provides a comprehensive review of various observational studies and randomized trials encompassing the use of anti-inflammatory agents in the management of AD patients and utilizes the conclusions derived therefrom to give recommendations in this regard.

Keywords: alzheimer disease; anti-inflammatory agents; cognitive impairment; degenerative disease; dementia; disease prevention; neuroinflammation; non-steroidal anti-inflammatory drugs (nsaid).

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Conflict of interest statement

The authors have declared that no competing interests exist.

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