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. 2019 Jun 19:6:607-615.
doi: 10.1016/j.toxrep.2019.06.012. eCollection 2019.

Protective efficacy using Cape- golden berry against pre-carcinogenic aflatoxins induced in rats

Ahmed Noah Badr  1 , Mohamed Ahmed Naeem  2
Affiliations

Protective efficacy using Cape- golden berry against pre-carcinogenic aflatoxins induced in rats

Ahmed Noah Badr et al. Toxicol Rep. .

Erratum in

Abstract

Aflatoxins are harmful compounds that induced carcinogenic impacts on tissues. It could generate oxidative stress causing cells damage. Bioactive substances from natural plants could avoid mycotoxins' bad impacts. Cape-goldenberry (CGB), a source of active substances, was vacuum-dried at 30 °C then milled. Fresh and dried CGB-powder properties were estimated. Animal experiment was designed using six rat-groups to evaluate CBG effect to reduce harmful effect of aflatoxins. Rats treated groups were orally administrated by aflatoxins (AFs) with or without CGB in diets. Blood parameters, liver and kidney functions, serum lipids, and liver histological changes were estimated. The CGB powder showed several time doubles of phenolics, flavonoids, and antioxidants than fresh fruits. Diet supplementation by CGB of AFs-treated rats showed enhancement in final weight, food efficiency, and weight gain compared to AFs treatment only. Also, liver and kidney functions, liver enzymes, iron level, tumors indicator, and serum lipids of AFs- rats. Moreover, total protein, albumin, and globulin reduction by AFs have been improved by CGB presence in diets. Histopathological studies for AFs-rats liver showed dilated blood sinusoids with aggregation of inflammatory, Kupffer cell hyperplasia, degenerated hepatocytes, and apoptotic cells. However, in AFs-rat groups fed CGB in diets, liver hepatocytes appeared to be almost normal similar to the control. Results pointed out that CGB recorded a corrective action for aflatoxin B1 and G1 toxicity. This was recorded for the blood and serum parameters, and liver enzymes. This CGB action avoiding AFs-toxicity was more clearly declared in the liver tissues.

Keywords: Aflatoxins; Biochemical parameters; Cape-golden berry; Carcinogenic impacts; Corrective action; Liver tissues.

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Figures

None
Graphical abstract
Fig. 1
Fig. 1
effect of Cap golden berry to limit serum proteins and serum antioxidant changes in aflatoxins-treated rats. ● Rats of aflatoxins treated groups were orally administrated by dose of 850 ng/kg body weight/day.
Fig. 2
Fig. 2
Liver functions of rats fed on cape-golden berry diet with/without aflatoxins orally administrated. ● Data expressed as means ± SD –; (n = 3; P = 0.05) –; CGB: Cape-golden berry. ● Oral administration of aflatoxin B1 or Aflatoxin G1 adjusted at 850 ng/kg body weight/day.
Fig. 3
Fig. 3
Liver tissues of rats fed diets contained a dried golden berry powder to avoided aflatoxins pre-carcinogenic impacts. ● Rats of aflatoxins treated groups were orally administrated by dose of 850 ng/kg body weight/day.
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