Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Oct;41(10):1195-1206.
doi: 10.1007/s13258-019-00849-z. Epub 2019 Jul 16.

Bioinformatic identification and expression analysis of the chicken B cell lymphoma (BCL) gene

Van Thai Than  1 , Ha Thi Thanh Tran  2 , Duc Viet Ly  2 , Hoang Vu Dang  2 , Minh Nam Nguyen  3 , Anh Duc Truong  4
Affiliations

Bioinformatic identification and expression analysis of the chicken B cell lymphoma (BCL) gene

Van Thai Than et al. Genes Genomics. 2019 Oct.

Abstract

Background: B cell lymphoma (BCL) families play an important role in apoptosis as a growth factor, cell death programming, cytokine expression and immune-related genes expression.

Objectives: In this study, to investigate the roles of BCLs, we performed genome-wide identification, expression and functional analyses of the BCL family in chicken.

Methods: Chicken BCLs genes were identified and analyzed by using bioinformatics approach. Expression profiles and Hierarchical cluster analysis of the BCLs genes in different chicken tissues were obtained from the genome-wide RNA-seq in the GEO, and Cluster and Java Treeview, respectively.

Results: A total of 16 BCLs genes were identified from the chicken genome, which could be further classified into five distinct groups in the phylogenetic tree. On the other hand, the interaction among BCLs proteins and between BCLs proteins with NF-κB subunits are limited, indicating that the remaining the functions of BCLs protein could be investigated in chicken. Moreover, KEGG pathway analysis indicated that BCL gene family was involved in regulation of apoptotic and immune response. Finally, BCL gene family was differentially expressed in chicken tissues, pathogen infection and growth stages of early chicken early embryo.

Conclusion: This study provides significant insights into the potential functions of BCLs in chicken, including the regulation of apoptosis, cell death and expression of immune-related genes.

Keywords: Apoptosis; B-cell lymphoma (BCL); Chicken; Immune; Pathway.

PubMed Disclaimer

References

    1. J Biol Chem. 2014 Dec 26;289(52):36001-17 - PubMed
    1. Leuk Lymphoma. 2007 Jun;48(6):1061-3 - PubMed
    1. Mol Reprod Dev. 1997 May;47(1):26-9 - PubMed
    1. Oncotarget. 2017 Dec 4;8(67):111656-111671 - PubMed
    1. Vet Immunol Immunopathol. 2017 May;187:1-9 - PubMed