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. 2019 Nov;30(6):720-726.
doi: 10.1002/pca.2852. Epub 2019 Jul 16.

Rapid identification of dragon blood samples from Daemonorops draco, Dracaena cinnabari and Dracaena cochinchinensis by MALDI-TOF mass spectrometry

Chunhung Wu  1 , Xin-Qi Cai  1 , Yu Chang  2 , Chueh-Hsuan Chen  1 , Tsung-Jung Ho  3   4 , Shang-Chih Lai  5   6 , Hao-Ping Chen  2   4
Affiliations

Rapid identification of dragon blood samples from Daemonorops draco, Dracaena cinnabari and Dracaena cochinchinensis by MALDI-TOF mass spectrometry

Chunhung Wu et al. Phytochem Anal. 2019 Nov.

Abstract

Introduction: Dragon blood is a deep-red plant resin which has been used as folk medicine for more than a thousand years. It can be produced from at least four entirely different plant families: Asparagaceae, Arecaceae, Chamaesyce, and Fabaceae. Current pharmacopeia states that the only "authentic" source of dragon blood is the palm tree, Daemonorops draco.

Objective: The present study aims to find a high-throughput method to screen and identify the plant sources of commercial dragon blood products.

Methodology: A matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) based method for rapid screening of dracorhodin in commercial dragon blood samples was established in this study.

Results: Well-resolved peaks of dracorhodin in spectra were observed in the crude extracts of samples. Dragon blood samples from two other plant species, Dracaena cinnabari and Dracaena cochinchinensis, were also examined. Their indicator compounds, loureirin A and B, were detected in these plants.

Conclusion: A MALDI-TOF based method for preliminarily examination of commercial dragon blood samples is reported here. In contrast to MALDI-TOF, liquid chromatography mass spectrometry (LC-MS) is a time-consuming and costly method, not ideal for routine and large-scale screening of commercial samples.

Keywords: MALDI-TOF; dracorhodin; dragon blood; loureirin A; loureirin B.

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References

REFERENCES

    1. Gupta D, Bleakley B, Gupta RK. Dragon's blood: botany, chemistry and therapeutic uses. J Ethnopharmacol. 2008;115(3):361-380.
    1. Namjoyan F, Kiashi F, Moosavi ZB, Saffari F, Makhmalzadeh BS. Efficacy of Dragon's blood cream on wound healing: a randomized, double-blind, placebo-controlled clinical trial. J Tradit Complement Med. 2015;6:37-40.
    1. Pieters L, De Bruyne T, Van Poel B, et al. In vivo wound healing activity of Dragon's blood (Croton spp.), a traditional south American drug, and its constituents. Phytomedicine. 1995;2(1):17-22.
    1. Department of Health, Hong Kong Special Administrative Region. Hong Kong Chinese Materia Medica strandards. 6 the People's Republic of China: Department of Health, Hong Kong Special Administrative Region; 2005:362-368.
    1. State Pharmacopoeia Commission of the PRC. Pharmacopoeia of the People's Republic of China. 1: Beijing: People's Medical Publishing House; 2015:142.

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