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. 2020 Aug;55(8):e4423.
doi: 10.1002/jms.4423. Epub 2019 Aug 9.

Rapid MALDI-TOF molecular imaging: Instrument enhancements and their practical consequences

Marvin Vestal  1 , Lingjun Li  2   3 , Evgenia Dobrinskikh  4 , Yatao Shi  2 , Bowen Wang  5 , Xudong Shi  6 , Sicheng Li  1 , Christina Vestal  1 , Kenneth Parker  1
Affiliations

Rapid MALDI-TOF molecular imaging: Instrument enhancements and their practical consequences

Marvin Vestal et al. J Mass Spectrom. 2020 Aug.

Abstract

A new high performance linear MALDI-TOF mass spectrometer provides both high spatial resolution and high speed. This instrument employs a new ion optics system with a grounded ion source and efficient transfer and detection of ions over a broad mass range. This provides very high sensitivity, precision, and an extended dynamic range for both positive and negative ion detection. Here we demonstrate the capabilities of this system by imaging pancreatic tissue samples from rats and mice.

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References

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