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Review

Metal Ions Introduced to Proteins by Supramolecular Ligands

Olga Woźnicka  1 , Joanna Rybarska  2 , Anna Jagusiak  2 , Leszek Konieczny  2 , Barbara Stopa  2 , Irena Roterman  3
Irena Roterman  1 , Leszek Konieczny  2
, editors.
In: Self-Assembled Molecules – New Kind of Protein Ligands: Supramolecular Ligands [Internet]. Cham (CH): Springer; 2018. Chapter 4.
.
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Review

Metal Ions Introduced to Proteins by Supramolecular Ligands

Olga Woźnicka et al.
Free Books & Documents

Excerpt

Congo red and other supramolecular structures may intercalate various foreign compounds, particularly planar ones. Such hybrid ligands, acting as a unit, may attach themselves to proteins and penetrate into their interior, together with any intercalated substances. If the intercalant is a metal complexone, a stable metalloprotein may be formed. This chapter discusses intercalation of metal complexones with metal ions bound by supramolecular Congo red as a means of introducing contrast to amyloid-like aggregates in order to trace the initial stages of amyloidogenesis. We investigate the applicability of Titan yellow carrying silver ions, and the alizarin complexone carrying tungsten and lead ions.

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